HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rämö, J. Articles by Ahonen, J. Search for Related Content PubMed Articles by Rämö, J. Articles by Ahonen, J. Related Collections Coronary disease

Ann Thorac Surg 2002;73:S374
© 2002 The Society of Thoracic Surgeons

---

SUPPLEMENT: OUTCOMES 2001: SCIENTIFIC ABSTRACTS

Cognitive change after coronary artery bypass surgery with a leukocyte-depleting filter

^a Department Of Thoracic and Cardiovascular Surgery, Helsinki University Central Hospital, Helsinki, Finland

Introduction. Cognitive decline is a significant form of end-organ damage after coronary artery bypass grafting (CABG). The aim of this study was to assess the protective effect of leukocyte-depleting filtration in cardiopulmonary bypass (CPB) circuit on neuropsychological performance and neurobiochemical markers.

Methods. Sixty consecutive patients undergoing CABG were randomized into filter and control groups. Neuropsychological assessment was conducted preoperatively, and 5 and 90 days after the operation. S-100ß and NSE levels were collected 6 and 24 hours after surgery, and complement 3 (C3) levels at 24 hours.

Results. Attentive functions, verbal memory, and learning (p = 0.07 and 0.12) were better at the early postoperative stage in the filter group. In filter group, the C3 levels were significantly lower at 24 hours, and S-100ß levels correlated with CPB duration but not with cognitive decline. In controls, S-100ß correlated only with cognitive decline. NSE levels increased equally in both groups, and 24-hour levels correlated with late cognitive decline (p = 0.05).

Conclusions. Leukocyte-depleting filtration of CPB may attenuate cognitive decline at the early stage after CABG, but ascertainment of the effect will require larger samples. Complement activation may be affected, and the filter is a potential confounding factor in assessment of the relationship between S100ß levels and cognitive decline.

This article has been cited by other articles:

				A. P. Furnary, Y. Wu, L. F. Hiratzka, G. L. Grunkemeier, and U. S. Page 3rd Aprotinin Does Not Increase the Risk of Renal Failure in Cardiac Surgery Patients Circulation, September 11, 2007; 116(11_suppl): I-127 - I-133. [Abstract] [Full Text] [PDF]

				A. Ronald and J. Dunning Does use of aprotinin decrease the incidence of stroke and neurological complications in adult patients undergoing cardiac surgery? Interactive CardioVascular and Thoracic Surgery, December 1, 2006; 5(6): 767 - 773. [Abstract] [Full Text] [PDF]

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rämö, J. Articles by Ahonen, J. Search for Related Content PubMed Articles by Rämö, J. Articles by Ahonen, J. Related Collections Coronary disease