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Ann Thorac Surg 2002;73:238-239
© 2002 The Society of Thoracic Surgeons

Invited commentary

Steven M. Fiser, MDa, Curtis G. Tribble, MDa

a Division of Thoracic and Cardiovascular Surgery, University of Virginia School of Medicine, Lane Rd, MR4 Building, Room 3116, Charlottesville, VA 22908-1359, USA

e-mail: ctribble{at}virginia.edu

Doctor Scherer and colleagues present convincing evidence that the complement pathway is involved in reperfusion injury following lung transplantation. It is interesting to note that as research in lung transplant research progresses, it becomes clear that many pathways, including inflammatory, coagulation, and complement, are involved in reperfusion injury.

Recently, our laboratory has shown that reperfusion injury following lung transplantation seems to occur in two phases. Our findings have shown that the first phase seems to be mediated by donor pulmonary macrophages. Recipient circulating leukocytes then mediate the second phase injury. This second phase also likely involves the complement and coagulation pathways. When reviewing this research in this area, one realizes the complex nature of reperfusion injury following lung transplantation. What still remains to be discovered is the inciting event which propels all of these pathways and what can be done to best prevent reperfusion injury.


Related Article

C1-esterase inhibitor reduces reperfusion injury after lung transplantation
Mirela Scherer, Stefanos Demertzis, Frank Langer, Anton Moritz, and Hans-Joachim Schäfers
Ann. Thorac. Surg. 2002 73: 233-238. [Abstract] [Full Text] [PDF]




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