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Ann Thorac Surg 2004;78:1772-1773
© 2004 The Society of Thoracic Surgeons

INVITED COMMENTARY

Roger A. Vertrees, PhD, CCP, Joseph B. Zwischenberger, MD

Department of Surgery, The University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555, USA

rvertree@utmb.edu
jzwische@utmb.edu

The first 20% of the full text of this article appears below.

Hyperthermia has a long history in the treatment of various forms of cancer dating back to Coley's work first published in 1893. The literature is replete with examples that demonstrate that hyperthermia is selectively lethal to various subsets of cancers. Currently, a major area of interest in cancer research is the selective induction of apoptosis in targeted neoplastic cells, not damaging normal cells. Although, many studies have shown that hyperthermia in the correct dosage may induce apoptosis, neither the mechanisms nor targets are clearly defined.

Cis-platinum, an alkylating antineoplastic agent enters the cell . . . [Full Text of this Article]






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