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Ann Thorac Surg 2004;77:252-253
© 2004 The Society of Thoracic Surgeons

Original article: general thoracic

Invited commentary

James S. Allan, MD

Division of Thoracic Surgery, Massachusetts General Hospital, 55 Fruit St, Blake 1570, Boston, MA 02114, USA

e-mail: jallan@partners.org

The first 20% of the full text of this article appears below.

The c-kit gene is a conserved proto-oncogene that codes for a growth factor receptor with tyrosine kinase activity. This 145 kDa receptor is also referred to as the Steel factor receptor, the mast/stem cell factor receptor, and CD117. It is constitutively expressed on pluripotent hematopoietic progenitor cells, melanocytes, and primordial germ cells, where it plays a crucial role in the development . . . [Full Text of this Article]






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