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Ann Thorac Surg 2007;84:988-994
© 2007 The Society of Thoracic Surgeons

Original Articles: General Thoracic

Seven-Day Artificial Lung Testing in an In-Parallel Configuration

Hitoshi Sato, MD, Grant W. Griffith, BS, Candice M. Hall, BS, LVT, John M. Toomasian, MS, Ronald B. Hirschl, MD, Robert H. Bartlett, MD, Keith E. Cook, PhD*

Department of Surgery, University of Michigan, Ann Arbor, Michigan

Accepted for publication March 5, 2007.

* Address correspondence to Dr Cook, 7679 Kresge I, 200 Zina Pitcher Pl, Ann Arbor, MI 48109 (Email: keicook{at}umich.edu).

Background: A thoracic artificial lung, the MC3 Biolung, is being developed as a bridge to lung transplantation or as a treatment for acute respiratory insufficiency.

Methods: The thoracic artificial lung was tested in 10 sheep with the goal of 7 days of respiratory support. The sheep were recovered from surgery and monitored awake for 7 days. Hemodynamics, blood gases, blood cell counts, and organ function were recorded, and after 7 days, all sheep were euthanized and necropsied.

Results: Seven sheep survived the full duration. Cardiac output and mean arterial blood pressure were unchanged, averaging 4.7 ± 0.8 L/min and 98 ± 10 mm Hg, respectively. Arterial oxygen tension and device oxygen transfer rate were also unchanged, averaging 110 ± 26 mm Hg and 97.7 ± 35 mL/min, respectively. Arterial carbon dioxide tension was within normal ranges during the entire experiment, averaging 37.4 ± 3.8 mm Hg. Artificial lung blood flow decreased from 51% ± 14% of cardiac output on day 1 to 30% ± 16% by day 7 because of changes in natural and artificial lung resistance. White blood cell counts were significantly elevated on days 5 and 7, and lastly, kidney and liver function remained normal, although signs of kidney infarction or hemorrhage were noted.

Conclusions: The thoracic artificial lung is suitable for 7-day attachment, but improvements in blood biocompatibility are warranted.




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 Ann. Thorac. Surg.Home page
H. Sato, C. M. Hall, N. G. Lafayette, J. R. Pohlmann, N. Padiyar, J. M. Toomasian, J. W. Haft, and K. E. Cook
Thirty-Day In-Parallel Artificial Lung Testing in Sheep
Ann. Thorac. Surg., October 1, 2007; 84(4): 1136 - 1143.
[Abstract] [Full Text] [PDF]


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