HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Author home page(s): Junji Yoshida Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Enatsu, S. Articles by Nagai, K. Search for Related Content PubMed PubMed Citation Articles by Enatsu, S. Articles by Nagai, K. Related Collections Lung - cancer

Ann Thorac Surg 2006;81:298-304
© 2006 The Society of Thoracic Surgeons

---

Original article: General thoracic

Pleural Lavage Cytology Before and After Lung Resection in Non-Small Cell Lung Cancer Patients

^a Department of Thoracic Oncology, National Cancer Center Hospital East, Kashiwa, Japan
^b Department of Pathology, National Cancer Center Research Institute East, Kashiwa, Japan
^c Second Department of Surgery, Fukuoka University School of Medicine, Fukuoka City, Japan

Accepted for publication June 27, 2005.

^_* Address correspondence to Dr Enatsu, Second Department of Surgery, Fukuoka University School of Medicine, 7-45-1, Nanakuma, Jonan-ku, Fukuoka City, Fukuoka, 814-0180, Japan (Email: md040004{at}cis.fukuoka-u.ac.jp).

BACKGROUND: The aim of this study was to analyze on a multivariate basis the prognostic significance of pre-resection and post-resection pleural lavage cytologies in surgically resected primary non-small cell lung cancer (NSCLC) patients, in relation to pathologic TNM factors in a large cohort of almost 1,200 patients.

METHODS: From August 1992 through March 2001, pleural lavage cytology (PLC) was performed in 1,214 NSCLC patients without pleural effusion or dissemination undergoing pulmonary resection. The cytologic evaluation was classified into three categories: negative, suggestive, and positive. To investigate the impact on patient survival, PLC results were analyzed with conventional clinicopathologic factors.

RESULTS: Definitive pre-resection PLC result was obtained in 1,194 patients and 38 had a positive result. The 5-year survival rates were 27% if pre-resection PLC was positive and 71% if negative. Of 1,198 patients 54 had a positive post-resection PLC result. The 5-year survival rates were 10% if post-resection PLC was positive and 73% if negative. On multivariate analysis, post-resection PLC was an independent prognostic factor as significant as established clinicopathologic factors.

CONCLUSIONS: Pre-resection and post-resection PLC should be recognized as an essential prognostic factor and should be performed in NSCLC patients without pleural effusion and dissemination. Post-PLC, compared with pre-PLC, had a greater and independent impact on survival and needs to be incorporated in the pathologic staging of NSCLC in the future.

This article has been cited by other articles:

				C.S. Pramesh, R. C. Mistry, J. Agarwal, and R. Bishnoi Should Pleural Fluid Cytology Be Incorporated in the TNM Staging System for Operable Nonsmall Cell Lung Cancer? Ann. Thorac. Surg., December 1, 2006; 82(6): 2338 - 2339. [Full Text] [PDF]

				S. Enatsu, J. Yoshida, M. Nishimura, Y. Nishiwaki, K. Nagai, T. Yokose, and T. Shirakusa Reply Ann. Thorac. Surg., December 1, 2006; 82(6): 2339 - 2340. [Full Text] [PDF]