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Ann Thorac Surg 2004;78:1928-1931
© 2004 The Society of Thoracic Surgeons

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Original Article: General Thoracic

Clinicopathological Analysis of Pulmonary Sclerosing Hemangioma

^a Department of Thoracic Surgery, Chiba, Japan
^b Department of Basic Pathology, Chiba University, Graduate School of Medicine
^c Department of Thoracic Surgery, Kimitsu Chuo Hospital, Chiba, Japan

Accepted for publication May 12, 2004.

^* Address reprint requests to Dr Fujisawa, Department of Thoracic Surgery, Chiba University, Graduate School of Medicine, Japan, 1–8–1, Inohana, Chuo-ku, Chiba 260–8670, Japan (E-mail: fujisawat{at}faculty.chiba-u.jp).

BACKGROUND: Sclerosing hemangiomas of the lung are uncommon tumors and are thought to be benign. However, the histogenesis and clinicopathological features of these tumors have not been elucidated.

METHODS: We analyzed the clinicopathological features of 26 sclerosing hemangiomas. The immunoreactivity for Ki-67 and p53 of sclerosing hemangiomas was determined and compared with that of pathological stage 1 pulmonary papillary adenocarcinomas.

RESULTS: The patients of sclerosing hemangioma were predominantly female. Eighteen patients were detected as a result of routine medical examinations and 15 were nonsmokers. Seven patients underwent tumor enucleation, 10 underwent a wedge resection, and 9 underwent a lobectomy. The mean tumor size was 2.2 cm (range 1 to 5 cm). Pathological findings demonstrated a papillary pattern in 23 cases, sclerotic pattern in 26 cases, hemorrhagic pattern in 22 cases and a solid pattern in 25 cases. Twenty-five cases had an excellent prognosis with no evidence of recurrence following surgery. However, 1 patient who had undergone a wedge resection developed a local recurrence and required an additional wedge resection. The Ki-67 labeling index of sclerosing hemangiomas was significantly lower than that of adenocarcinomas, whereas the Ki-67 labeling index of the recurrent case was 0.4%. No significant immunohistochemical staining for p53 was observed in sclerosing hemangioma cases.

CONCLUSIONS: Sclerosing hemangioma exhibits various histologic findings. Although we experienced one case with a recurrent tumor, sclerosing hemangiomas did not exhibit malignant behavior.

This article has been cited by other articles:

				Y Wang, S-D Dai, F-J Qi, H-T Xu, and E-H Wang p53 protein expression and genetic mutation in two primary cell types in pulmonary sclerosing haemangioma J. Clin. Pathol., February 1, 2008; 61(2): 192 - 196. [Abstract] [Full Text] [PDF]