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Ann Thorac Surg 2004;78:1248-1255
© 2004 The Society of Thoracic Surgeons
a Harrison Department of Surgical Research, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
Accepted for publication April 1, 2004.
* Address reprint requests to Dr Joseph Gorman, Department of Surgery, 6 Silverstein, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
gormanj{at}uphs.upenn.edu
BACKGROUND: The anterior mitral annulus is considered a fixed structure. Recent data suggest otherwise. This study tested the hypothesis that the size of the anterior annulus varies with hemodynamic loading and ventricular contractility.
METHODS: Sonomicrometry array localization measured annular area, total annular circumference, anterior circumference, and posterior circumference in 6 sheep before and after neosynephrine increased systolic blood pressure by at least 150% during atrial pacing at 120 beats/min. In 6 additional animals the same dimensions were measured during atrial pacing (at 120 and 150 beats/min) and during isoproteronol infusions to increase heart rate to 120 and 150 beats/min.
RESULTS: Neosynephrine increased systolic total annular circumference from 99.7 ± 5.5 mm to 106.9 ± 9.6 mm. Anterior circumference increased from 40.8 ± 4.0 mm to 45.3 ± 5.7 mm whereas posterior circumference only increased from 59.0 ± 5.5 mm to 61.6 ± 7.0 mm. Low isoproteronol infusion decreased systolic total annular circumference from 107.5 ± 8.3 mm to 101.9 ± 10.6 mm. Most of this change occurred in the posterior circumference. Higher infusions of isoproteronol decreased total annular circumference from 106.8 ± 8.3 mm to 98.3 ± 9.7 mm. At this higher inotropic state the decrease in annular size was similar in the anterior and posterior annulus.
CONCLUSIONS: In sheep, the anterior annulus is a dynamic structure that varies in size in response to changes in hemodynamic loading and ventricular contractility.
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