| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 2004;78:216-221
© 2004 The Society of Thoracic Surgeons
a Department of Thoracic Surgery, Hyogo Medical Center for Adults, Akashi City, Hyogo, Japan
Accepted for publication February 3, 2004.
* Address reprint requests to Dr Okada, Department of Thoracic Surgery, Hyogo Medical Center for Adults, Kitaohji-cho13-70, Akashi City 673-8558, Hyogo, Japan
e-mail: morihito1217jp{at}aol.com
BACKGROUND: The prognostic implication of serum carcinoembryonic antigen (CEA) has yet to be comprehensively analyzed since the reports available so far have comprised small patient populations. We evaluated perioperative CEA values with regard to surgical results in a large number of patients to clarify its merit.
METHODS: We measured serum CEA levels before and after surgery in 1,000 consecutive patients with clinical stage I non-small cell lung cancer who underwent resection of tumor. High CEA value was greater than 5.0 ng/mL.
RESULTS: Three hundred and sixty-eight patients (36.8%) had high preoperative CEA levels. The CEA levels after surgery were normalized in 242 patients (24.2%) and persistently elevated in 126 patients (12.6%). High CEA levels were seen more frequently in patients with older age, male gender, larger size of tumor, incomplete resection, and advanced pathologic stage. Patients with a high preoperative CEA level had a poor survival. Among these patients, even worse survival was seen for those with a high postoperative CEA level. These prognostic trends were still observed for patients with pathologic stage I disease. Multivariate analysis demonstrated that both preoperative and postoperative CEA levels were independent prognostic determinants (p = 0.0243 and p < 0.0001, respectively).
CONCLUSIONS: Perioperative measurement of serum CEA concentrations yields information valuable for detecting patients at high risk of poor survival. Normalization of CEA levels after surgery was a significant favorable prognostic sign in patients with an elevated CEA level before surgery. Even after apparently successful surgical therapy, patients with a high CEA level should be carefully followed up, and might represent a suitable target for neoadjuvant clinical trials.
This article has been cited by other articles:
|
|
 |
|
  H. Matsuguma, R. Nakahara, S. Igarashi, Y. Ishikawa, H. Suzuki, N. Miyazawa, S. Honjo, and K. Yokoi Pathologic stage I non small cell lung cancer with high levels of preoperative serum carcinoembryonic antigen: Clinicopathologic characteristics and prognosis J. Thorac. Cardiovasc. Surg., January 1, 2008; 135(1): 44 - 49. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Matsuoka, S. Sumitomo, N. Nakashima, D. Nakajima, and N. Misaki Prognostic value of carcinoembryonic antigen and CYFRA21-1 in patients with pathological stage I non-small cell lung cancer Eur. J. Cardiothorac. Surg., September 1, 2007; 32(3): 435 - 439. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Fukai, Y. Sakao, M. Sakuraba, S. Oh, K. Shiomi, S. Sonobe, Y. Saitoh, and H. Miyamoto The prognostic value of carcinoembryonic antigen in T1N1M0 and T2N1M0 non-small cell carcinoma of the lung Eur. J. Cardiothorac. Surg., September 1, 2007; 32(3): 440 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Okada, S. Tauchi, K. Iwanaga, T. Mimura, Y. Kitamura, H. Watanabe, S. Adachi, T. Sakuma, and C. Ohbayashi Associations among bronchioloalveolar carcinoma components, positron emission tomographic and computed tomographic findings, and malignant behavior in small lung adenocarcinomas J. Thorac. Cardiovasc. Surg., June 1, 2007; 133(6): 1448 - 1454. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W.-H. Hsu, C.-S. Huang, H.-S. Hsu, W.-J. Huang, H.-C. Lee, B.-S. Huang, and M.-H. Huang Preoperative Serum Carcinoembryonic Antigen Level is a Prognostic Factor in Women With Early Non-Small-Cell Lung Cancer Ann. Thorac. Surg., February 1, 2007; 83(2): 419 - 424. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. A. D'Amico, K. R. Brooks, M.-B. M. Joshi, D. Conlon, J. Herndon II, R. P. Petersen, and D. H. Harpole Jr Serum Protein Expression Predicts Recurrence in Patients With Early-Stage Lung Cancer After Resection Ann. Thorac. Surg., June 1, 2006; 81(6): 1982 - 1987. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Inoue, M. Minami, H. Shiono, N. Sawabata, K. Ideguchi, and M. Okumura Clinicopathologic study of resected, peripheral, small-sized, non-small cell lung cancer tumors of 2 cm or less in diameter: Pleural invasion and increase of serum carcinoembryonic antigen level as predictors of nodal involvement J. Thorac. Cardiovasc. Surg., May 1, 2006; 131(5): 988 - 993. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. R. Mulligan, A. D. Meram, C. D. Proctor, H. Wu, K. Zhu, and A. J. Marrogi Unlimited Access to Care: Effect on Racial Disparity and Prognostic Factors in Lung Cancer Cancer Epidemiol. Biomarkers Prev., January 1, 2006; 15(1): 25 - 31. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Tomita, T. Shimizu, Y. Matsuzaki, M. Hara, T. Ayabe, and T. Onitsuka Prognostic Significance of Carcinoembryonic Antigen Level in Pleural Lavage Fluid for Patients With Lung Adenocarcinoma Ann. Thorac. Surg., July 1, 2005; 80(1): 276 - 281. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
