| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 2004;77:271-277
© 2004 The Society of Thoracic Surgeons
a The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
* Address reprint requests to Dr Yang, 624 Osler, 600 N. Wolfe St, Baltimore, MD 21287, USA
e-mail: syang{at}jhmi.edu
Presented at the Poster Session of the Thirty-ninth Annual Meeting of The Society of Thoracic Surgeons, San Diego, CA, Jan 31–Feb 2, 2003.
BACKGROUND: Recent reports indicate that age is not a contraindication to pulmonary resection for octogenarians with nonsmall cell lung cancer (NSCLC), but other data are lacking. The purpose of this study was to determine outcomes in these patients, particularly short- and long-term survival with stage I disease.
METHODS: A retrospective cohort of 68 octogenarians with NSCLC who underwent curative resection from 1980 to 2002 was followed-up for outcomes.
RESULTS: Median age was 82 years old (range, 80–87 years old) consisting of 44 males (65%), with a mean follow-up of 32 months (range, 1–178 months). Operations included: 47 lobectomies (69%), 11 wedge resections (16%), 5 segmentectomies (8%), 4 bilobectomies (6%), and 1 pneumonectomy (1%). There were 31 adenocarcinomas (46%), 18 squamous carcinomas (26%), 12 bronchioalveolar carcinomas (18%), 4 large cell carcinomas (6%), and 3 miscellaneous malignant neoplasms (4%). Median hospital stay was 7 days (range, 3–53 days). Thirty-day mortality was 8.8% (n = 6) with 83% developing cardiopulmonary complications. Overall actuarial survival at 1, 3, and 5 years was 73%, 51%, and 34%, respectively. Of 41 patients (60%) with stage I disease, 23 were T1 lesions. Five-year survival was significantly different between stages Ia and Ib patients (61% and 10%, respectively, p = 0.001). Patients in more advanced stages had a 5-year survival of 3/27 (11%). Multivariate analysis identified advanced tumor stage, lower ASA physical status, and low FEV1 as factors associated with poorer long-term survival.
CONCLUSIONS: The 5-year survival, particularly in patients with stage Ia tumors with favorable ASA and FEV1, supports the notion that health status and tumor stage outweigh chronologic age in determining surgical candidates.
This article has been cited by other articles:
|
|
 |
|
  W. K. Bernstein and S. Deshpande Preoperative Evaluation for Thoracic Surgery Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2008; 12(2): 109 - 121. [Abstract] [PDF]
|
|
|
|
 |
|
 F. Farjah, D. E. Wood, D. Yanez III, R. G. Symons, B. Krishnadasan, and D. R. Flum Temporal trends in the management of potentially resectable lung cancer. Ann. Thorac. Surg., June 1, 2008; 85(6): 1850 - 1855. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G A Silvestri and S G Spiro Carcinoma of the bronchus 60 years later Postgrad. Med. J., April 1, 2008; 84(990): 182 - 187. [Full Text] [PDF]
|
|
|
|
 |
|
 M. V. Brock, C. M. Hooker, E. Ota-Machida, Y. Han, M. Guo, S. Ames, S. Glockner, S. Piantadosi, E. Gabrielson, G. Pridham, et al. DNA Methylation Markers and Early Recurrence in Stage I Lung Cancer N. Engl. J. Med., March 13, 2008; 358(11): 1118 - 1128. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Mun and T. Kohno Video-Assisted Thoracic Surgery for Clinical Stage I Lung Cancer in Octogenarians Ann. Thorac. Surg., February 1, 2008; 85(2): 406 - 411. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. L. Colice, S. Shafazand, J. P. Griffin, R. Keenan, and C. T. Bolliger Physiologic Evaluation of the Patient With Lung Cancer Being Considered for Resectional Surgery: ACCP Evidenced-Based Clinical Practice Guidelines (2nd Edition) Chest, September 1, 2007; 132(3_suppl): 161S - 177S. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dominguez-Ventura, S. D. Cassivi, M. S. Allen, D. A. Wigle, F. C. Nichols, P. C. Pairolero, and C. Deschamps Lung cancer in octogenarians: factors affecting long-term survival following resection Eur. J. Cardiothorac. Surg., August 1, 2007; 32(2): 370 - 374. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. H. Moskovitz, N. P. Rizk, E. Venkatraman, M. S. Bains, R. M. Flores, B. J.H. Park, and V. W. Rusch Mortality Increases for Octogenarians Undergoing Esophagogastrectomy for Esophageal Cancer Ann. Thorac. Surg., December 1, 2006; 82(6): 2031 - 2036. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G A Silvestri and S G Spiro Carcinoma of the bronchus 60 years later. Thorax, December 1, 2006; 61(12): 1023 - 1028. [Full Text] [PDF]
|
|
|
|
|
|
A. Dominguez-Ventura, M. S. Allen, S. D. Cassivi, F. C. Nichols III, C. Deschamps, and P. C. Pairolero Lung cancer in octogenarians: factors affecting morbidity and mortality after pulmonary resection. Ann. Thorac. Surg., October 1, 2006; 82(4): 1175 - 1179. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Sirbu, W. Schreiner, H. Dalichau, and T. Busch Surgery for Non-Small Cell Carcinoma in Geriatric Patients: 15-Year Experience Asian Cardiovasc Thorac Ann, December 1, 2005; 13(4): 330 - 336. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Matsuoka, M. Okada, T. Sakamoto, and N. Tsubota Complications and outcomes after pulmonary resection for cancer in patients 80 to 89 years of age Eur. J. Cardiothorac. Surg., September 1, 2005; 28(3): 380 - 383. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Port, M. Kent, R. J. Korst, P. C. Lee, M. A. Levin, D. Flieder, and N. K. Altorki Surgical Resection for Lung Cancer in the Octogenarian Chest, September 1, 2004; 126(3): 733 - 738. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
