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Right arrow Esophagus - cancer

Ann Thorac Surg 2002;74:1924-1927
© 2002 The Society of Thoracic Surgeons

Original article: general thoracic

Small cell carcinoma of the esophagus: the Tata Memorial Hospital experience

Gouri H. Pantvaidya, MSa*, C.S. Pramesh, MS, FRCSa, Mandar S. Deshpande, MSa, Nirmala A. Jambhekar, MDb, Sanjay Sharma, MS, FICSa, Ramakant K. Deshpande, MS, FICSa

a Department of Surgical Oncology, Tata Memorial Hospital, Mumbai, India
b Department of Pathology, Tata Memorial Hospital, Mumbai, India

Accepted for publication July 10, 2002.

* Address reprint requests to Dr Pantvaidya, Department of Surgical Oncology, Tata Memorial Hospital, Mumbai 400012, India.
e-mail: docgouri{at}yahoo.com

BACKGROUND: Small cell carcinoma of the esophagus is a rare disease, characterized by aggressive progression. It has a high incidence of metastatic disease at presentation and a poor overall prognosis. Treatment protocols are not well established because of the paucity of cases and a lack of large studies.

METHODS: We performed a retrospective review of all patients with small cell carcinoma of the esophagus diagnosed at the Tata Memorial Hospital between 1985 and 2001. We retrieved and analyzed data regarding demographic details, diagnosis, staging, type of treatment, and overall survival.

RESULTS: Eighteen patients with a mean age of 62 years (range 48 to 80 years) diagnosed as having small cell carcinoma of the esophagus were analyzed. The group included 13 men and 5 women. Seven of the 18 patients (39%) presented with metastatic disease including 5 patients (28%) with liver metastases. Four patients were treated with surgery, with or without chemotherapy or radiotherapy. Three patients were treated with combination chemoradiotherapy, 2 patients with chemotherapy alone, and 5 patients with radiotherapy alone. Four patients with advanced disease and poor general condition were not offered any treatment. The overall median survival of our patients was 6 months. Patients treated with surgery and chemotherapy had a better overall survival.

CONCLUSIONS: Small cell carcinoma of the esophagus should be regarded as a systemic disease with a high distant failure rate. Treatment strategies hence must incorporate systemic chemotherapy along with radical surgery or radiotherapy as part of a multimodality approach.




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[Abstract] [Full Text] [PDF]


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