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Ann Thorac Surg 2002;73:1747-1751
© 2002 The Society of Thoracic Surgeons

Original article: general thoracic

Survival analysis of rats implanted with porous titanium tracheal prosthesis

Philippe Schultz, MDa, Dominique Vautier, PhDb, Johanna Chluba, PhDb, Luc Marcellin, MDc, Christian Debry, MD, PhD*a

a Department of Otolaryngology-Head and Neck Surgery, Hautepierre Hospital, Strasbourg, France
b Department of Anatomo-Pathology, Hautepierre Hospital, Strasbourg, France
c INSERM 424, Centre de Recherche Odontologique, Strasbourg, France

Accepted for publication February 26, 2002.

* Address reprint requests to Prof Debry, Hôpital de Hautepierre, Avenue Molière, 67098 Strasbourg Cedex, France
e-mail: christian.debry{at}chru-strasbourg.fr

Background. Surgical treatment of a malignancy in the trachea may lead to a long resection that has to be reconstructed with an artificial prosthesis. However, most of the available prostheses encounter inflammatory rejection and mechanical constraint problems. To improve tracheal rehabilitation a porous titanium prosthesis was developed. The aim of this study was to test the biocompatibility of this novel material.

Results. Fibroblast colonization of titanium pores and a ciliary cylindrical epithelial layer developed on the endoluminal side of the prosthesis and the inflammatory reaction was minimal.

Conclusions. The results of this short-term study validate, from surgical and histologic standpoints, the usefulness of a porous titanium tracheal prosthesis.






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