ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iyoda, A.
Right arrow Articles by Fujisawa, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iyoda, A.
Right arrow Articles by Fujisawa, T.
Related Collections
Right arrow Lung - cancer

Ann Thorac Surg 2002;73:1049-1054
© 2002 The Society of Thoracic Surgeons

Original article: general thoracic

Pulmonary large cell carcinomas with neuroendocrine features are high-grade neuroendocrine tumors

Akira Iyoda, MDa, Kenzo Hiroshima, MDb, Masayuki Baba, MDa, Yukio Saitoh, MDa, Hidemi Ohwada, MDb, Takehiko Fujisawa, MD*a

a Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
b Department of Basic Pathology, Graduate School of Medicine, Chiba University, Chiba, Japan

Accepted for publication December 16, 2001.

* Address reprint requests to Dr Fujisawa, Department of Thoracic Surgery, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan
e-mail: fujisawa{at}med.m.chiba-u.ac.jp

Background. In 1999, the World Health Organization (WHO) categorized large cell carcinoma with neuroendocrine features as variants of large cell carcinoma and reclassified neuroendocrine lung tumors, especially typical and atypical carcinoid tumors. However, to date, the clinical relationship between these categories of neuroendocrine lung tumors has not been clearly defined.

Methods. We analyzed 133 cases of neuroendocrine tumors from primary lung carcinoma cases surgically resected. Using electron microscopy and immunohistochemical staining, we classified these cases as typical carcinoid (TC), atypical carcinoid (AC), large cell carcinoma with neuroendocrine features (LCNF), or small cell lung carcinoma (SCLC) based upon the WHO classification.

Results. TC and AC tumors were not related to smoking (p < 0.001) and, unlike LCNF, were found in younger patients (p < 0.001) without a male predominance (p < 0.001). Multivariate analysis revealed that LCNF predicted poorer overall and disease-free survivals comparable with SCLC (overall survival, p = 0.019, hazards ratio, 6.34; disease-free survival, p = 0.007, hazards ratio, 8.19).

Conclusions. The prognoses of LCNF are comparable with those of SCLC, and LCNF should be classified as high-grade neuroendocrine tumors.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
A. Iyoda, K. Hiroshima, Y. Nakatani, and T. Fujisawa
Pulmonary Large Cell Neuroendocrine Carcinoma: Its Place in the Spectrum of Pulmonary Carcinoma
Ann. Thorac. Surg., August 1, 2007; 84(2): 702 - 707.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Iyoda, K. Hiroshima, Y. Moriya, Y. Takiguchi, Y. Sekine, K. Shibuya, T. Iizasa, H. Kimura, Y. Nakatani, and T. Fujisawa
Prospective Study of Adjuvant Chemotherapy for Pulmonary Large Cell Neuroendocrine Carcinoma
Ann. Thorac. Surg., November 1, 2006; 82(5): 1802 - 1807.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
A. Iyoda, K. Hiroshima, Y. Moriya, Y. Sekine, K. Shibuya, T. Iizasa, Y. Nakatani, and T. Fujisawa
Prognostic impact of large cell neuroendocrine histology in patients with pathologic stage Ia pulmonary non-small cell carcinoma.
J. Thorac. Cardiovasc. Surg., August 1, 2006; 132(2): 312 - 315.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
G. Rossi, A. Cavazza, A. Marchioni, L. Longo, M. Migaldi, G. Sartori, N. Bigiani, L. Schirosi, C. Casali, U. Morandi, et al.
Role of Chemotherapy and the Receptor Tyrosine Kinases KIT, PDGFR{alpha}, PDGFR{beta}, and Met in Large-Cell Neuroendocrine Carcinoma of the Lung
J. Clin. Oncol., December 1, 2005; 23(34): 8774 - 8785.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. M. Ab' Saber, L. M. Massoni Neto, C. P. Bianchi, B. B. Ctenas, E. R. Parra, E. M. Eher, J. C. Pereira, T. Takagaki, N. H. Yamaguchi, and V. L. Capelozzi
Neuroendocrine and biologic features of primary tumors and tissue in pulmonary large cell carcinomas
Ann. Thorac. Surg., June 1, 2004; 77(6): 1883 - 1890.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
A. Iyoda, K. Hiroshima, Y. Moriya, T. Mizobuchi, M. Otsuji, Y. Sekine, K. Shibuya, T. Iizasa, Y. Saitoh, and T. Fujisawa
Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity
Ann. Thorac. Surg., June 1, 2004; 77(6): 1891 - 1895.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. Doddoli, F. Barlesi, B. Chetaille, L. Garbe, P. Thomas, R. Giudicelli, and P. Fuentes
Large cell neuroendocrine carcinoma of the lung: an aggressive disease potentially treatable with surgery
Ann. Thorac. Surg., April 1, 2004; 77(4): 1168 - 1172.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
C. Casali, A. Stefani, G. Rossi, M. Migaldi, S. Bettelli, A. Parise, and U. Morandi
The prognostic role of c-kit protein expression in resected large cell neuroendocrine carcinoma of the lung
Ann. Thorac. Surg., January 1, 2004; 77(1): 247 - 252.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 2002 by The Society of Thoracic Surgeons.