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Ann Thorac Surg 2002;73:37-43
© 2002 The Society of Thoracic Surgeons

Original article: cardiovascular

Clinical outcome in patients with 19-mm and 21-mm St. Jude aortic prostheses: comparison at long-term follow-up

Aldo D. Milano, MDa, Marco De Carlo, MDb, Gianclaudio Mecozzi, MDa, Alessandro D’Alfonso, MDa, Giovanni Scioti, MDa, Carmela Nardi, MDb, Uberto Bortolotti, MD*a

a Division of Cardiac Surgery, Cardio-Thoracic Department, University of Pisa Medical School, Pisa, Italy
b Division of Cardiology, Cardio-Thoracic Department, University of Pisa Medical School, Pisa, Italy

Accepted for publication August 31, 2001.

* Address reprint requests to Dr Bortolotti, U.O. Cardiochirurgia, Ospedale Cisanello, via Paradisa 2, 56124 Pisa, Italy
e-mail: u.bortolotti{at}cardchir.med.unipi.it

Background. Small-sized prostheses for aortic valve replacement may result in residual left ventricular outflow tract obstruction. Aim of the study was to verify whether implantation of 19-mm versus 21-mm St. Jude Medical standard prostheses (St. Jude Medical, Inc, St. Paul, MN) influences long-term clinical outcome.

Methods. Two hundred twenty-nine patients who underwent aortic valve replacement with 19 mm (group 1, 53 patients) or 21-mm St. Jude Medical standard prostheses (group 2, 176 patients) were included in the study. Mean follow-up of current survivors was 10 ± 4 years.

Results. Operative mortality was 7.5% in group 1 and 8.5% in group 2. At discharge, an important patient-prosthesis mismatch (effective orifice area index <= 0.60 cm2/m2) was present in 18% of group 1 versus 5% in group 2 (p = 0.004). Among patients with body surface area less than 1.70 m2, such mismatch was present in 15% of group 1 versus 2% of group 2 (p = 0.008). At last follow-up New York Heart Association (NYHA) functional class (p < 0.001), left ventricular mass reduction (p = 0.02), mean (p = 0.002) and peak transprosthetic gradients (p < 0.001), and effective orifice area index (p = 0.005) were significantly better in group 2. Freedom from sudden death (92% ± 5% vs 99% ± 1%, p = 0.01), valve-related death (84% ± 6% vs 90% ± 5%, p = 0.02), and cardiac events (56% ± 13% vs 86% ± 4%, p = 0.008), were significantly lower in group 1. Effective orifice area index was an independent predictor of late cardiac events.

Conclusions. Although long-term results after aortic valve replacement with small-sized St. Jude Medical standard prostheses are satisfactory, 19-mm valve recipients show a high prevalence of important patient-prosthesis mismatch with less evident functional improvement and higher rate of cardiac events, suggesting a very cautious use of this prosthesis.




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