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Ann Thorac Surg 2001;71:S125-S132
© 2001 The Society of Thoracic Surgeons
a Cullen Cardiovascular Surgical Research Laboratories, Texas Heart Institute, Houston, Texas, USA
b Jarvik Heart, Inc, New York, New York, USA
c Oxford Heart Centre, Oxford, England, United Kingdom
Address reprint requests to Dr Frazier, Texas Heart Institute, PO Box 20345, MC 3-147, Houston, TX 77225-0345
Presented at the Fifth International Conference on Circulatory Support Devices for Severe Cardiac Failure, New York, NY, Sept 15–17, 2000.
Abstract
Advances in technology and increased clinical need have led to the development of a new type of blood pump. The Jarvik 2000 Heart is an electrically powered, axial-flow left ventricular assist device that has been developed during the past 13 years. Unlike first-generation left ventricular assist devices, which were developed in the 1970s and were designed to totally capture the cardiac output, the Jarvik 2000 is designed to normalize the cardiac output by augmenting the function of the chronically failed heart for extended periods. Design iterations have been tested in 67 animals, and clinical trials have recently begun. Three patients have received the Jarvik 2000 as a bridge to transplantation, and 1 patient is being supported permanently outside the hospital. All 4 patients have improved from New York Heart Association functional class IV to class I, and 2 of them have been discharged from the hospital after heart transplantation. The experimental and clinical results indicate that the Jarvik 2000 can provide physiologic support with minimal complications and is reliable, biocompatible, and easy to implant.
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