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Ann Thorac Surg 1999;67:120-123
© 1999 The Society of Thoracic Surgeons

Original Articles

Temporary luminal arteriotomy seal: III. Postmortem arteriosclerotic human coronary artery

Robin H. Heijmen, MDa, Cornelius Borst, MD, PhDa, Chantal M. Mouës, MDa, Yvonne J.M. van der Helm, MDa, Paul F. Gründeman, MD, PhDa, Gerard Pasterkamp, MD, PhDb

a Department of Cardiology, Utrecht University Hospital, Utrecht, The Netherlands
b Department of Functional Anatomy, Utrecht University Hospital, Utrecht, the Netherlands

Accepted for publication June 23, 1998.

Address reprint requests to Dr Borst, Utrecht University Hospital (Room G02.523), P.O. Box 85500, 3508 GA Utrecht, the Netherlands
e-mail: exp.cardio{at}hli.azu.nl

Background. Recently, we described a temporary luminal arteriotomy seal that provided a bloodless arteriotomy without obstructing recipient artery blood flow during bypass grafting in nonarteriosclerotic porcine arteries. This postmortem study assessed the sealing properties in irregular arteriosclerotic human coronary arteries.

Methods. Three hearts were obtained from donated corpses within 24 hours of death. The coronary arteries were pressure-perfused at 60 mm Hg with citrated porcine blood. At 15 anastomosis sites in four different coronary arteries, an end-to-side anastomosis was created using a 200-µm-thick polyurethane seal. Adequacy of sealing was determined at perfusion pressures of 60, 40, and 20 mm Hg.

Results. After insertion, the arteriotomy was sealed instantaneously in 10 of 15 anastomoses. After repositioning, complete sealing with a bloodless operative field was obtained in all cases. Low intracoronary transmural pressure did not impede sealing. In 8 of 15 anastomoses, minor leakage without obscuring the arteriotomy edges was observed during anastomotic suturing. Histologic examination revealed no intimal tear or dissection caused by the anastomotic procedure.

Conclusions. In postmortem-obtained arteriosclerotic human coronary arteries, the temporary luminal arteriotomy seal provided optimal visualization of the coronary anastomosis site in combination with persistent distal perfusion.






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