ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Walter Weder
Ralph A. Schmid
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Weder, W.
Right arrow Articles by Steinert, H. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Weder, W.
Right arrow Articles by Steinert, H. C.

Ann Thorac Surg 1998;66:886-893
© 1998 The Society of Thoracic Surgeons

Original articles: General Thoracic

Detection of extrathoracic metastases by positron emission tomography in lung cancer

Walter Weder, MDa, Ralph A. Schmid, MDa, Helke Bruchhaus, MDb, Sven Hillinger, MDa, Gustav K. von Schulthess, MDb, Hans C. Steinert, MDb

a Department of Surgery, Department of Radiology, University Hospital, Zürich, Switzerland
b Division of Nuclear Medicine, Department of Radiology, University Hospital, Zürich, Switzerland

Address reprint requests to Dr Weder, Department of Surgery, University Hospital, Rämistr 100, CH-8091 Zürich, Switzerland

Presented at the Thirty-fourth Annual Meeting of The Society of Thoracic Surgeons, New Orleans, LA, Jan 26–28, 1998.

Background. Accurate staging of non–small cell lung cancer is essential for treatment planning. We evaluated in a prospective study the role of whole-body 2-[18F]fluoro-2-deoxy-D-glucose (FDG) positron emission tomography (PET) in mediastinal nodal staging with a positive predictive value of 96%. The study was continued to further evaluate the value of whole-body FDG PET in detecting unexpected extrathoracic metastases (ETMs) in patients qualifying for surgical treatment by conventional staging.

Methods. One hundred patients underwent clinical evaluation, chest and upper abdominal computed tomography scan, mediastinoscopy (lymph nodes greater than 1 cm on computed tomography), and routine laboratory tests. In 94 patients with stage IIIa or less and 6 with suspected N3 a whole-body FDG PET was performed. If clinical signs of ETMs were present additional diagnostic methods were applied. All findings in the FDG PET were confirmed histologically or radiologically.

Results. Unexpected ETMs were detected in 13 (14%) of 94 patients (stage IIIa or less) at 14 sites. In addition 6 of 94 patients were restaged up to N3 after PET. The suspected N3 disease (stage IIIb) on computed tomography was confirmed by PET in all 6 patients. There was no false positive finding of ETM. Weight loss was correlated with the occurrence of ETM: more than 5 kg, 5 of 13 patients (38%); more than 10 kg, 4 of 6 patients (67%). Pathologic laboratory findings were not predictive for ETM.

Conclusions. Whole-body FDG PET improves detection of ETMs in patients with non–small cell lung cancer otherwise elegible for operation. In 14% of patients (stage IIIa or less), ETMs were detected, and in total, 20% of the patients were understaged.




This article has been cited by other articles:


Home page
 JNCI J Natl Cancer InstHome page
Y. C. Ung, D. E. Maziak, J. A. Vanderveen, C. A. Smith, K. Gulenchyn, C. Lacchetti, W. K. Evans, and Lung Cancer Disease Site Group of Cancer Care Onta
18Fluorodeoxyglucose Positron Emission Tomography in the Diagnosis and Staging of Lung Cancer: A Systematic Review
J Natl Cancer Inst, December 5, 2007; 99(23): 1753 - 1767.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
G. A. Silvestri, M. K. Gould, M. L. Margolis, L. T. Tanoue, D. McCrory, E. Toloza, and F. Detterbeck
Noninvasive Staging of Non-small Cell Lung Cancer: ACCP Evidenced-Based Clinical Practice Guidelines (2nd Edition)
Chest, September 1, 2007; 132(3_suppl): 178S - 201S.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
K. E. Posther, L. M. McCall, D. H. Harpole Jr., C. E. Reed, J. B. Putnam Jr., V. W. Rusch, and B. A. Siegel
Yield of Brain 18F-FDG PET in Evaluating Patients with Potentially Operable Non-Small Cell Lung Cancer
J. Nucl. Med., October 1, 2006; 47(10): 1607 - 1611.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
J. L. Port, R. S. Andrade, M. A. Levin, R. J. Korst, P. C. Lee, D. E. Becker, and N. K. Altorki
Positron emission tomographic scanning in the diagnosis and staging of non-small cell lung cancer 2 cm in size or less
J. Thorac. Cardiovasc. Surg., December 1, 2005; 130(6): 1611 - 1615.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
V. W. Rusch
Mediastinoscopy: An Endangered Species?
J. Clin. Oncol., November 20, 2005; 23(33): 8283 - 8285.
[Full Text] [PDF]

Home page
 JCOHome page
F. Pozo-Rodriguez, J. L. Martin de Nicolas, M. A. Sanchez-Nistal, A. Maldonado, S. Garcia de Barajas, R. Calero-Garcia, M. A. Pozo, P. Martin-Escribano, I. Martin-Garcia, R. Garcia-Lujan, et al.
Accuracy of Helical Computed Tomography and [18F] Fluorodeoxyglucose Positron Emission Tomography for Identifying Lymph Node Mediastinal Metastases in Potentially Resectable Non-Small-Cell Lung Cancer
J. Clin. Oncol., November 20, 2005; 23(33): 8348 - 8356.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. Lardinois, W. Weder, M. Roudas, G. K. von Schulthess, M. Tutic, H. Moch, R. A. Stahel, and H. C. Steinert
Etiology of Solitary Extrapulmonary Positron Emission Tomography and Computed Tomography Findings in Patients With Lung Cancer
J. Clin. Oncol., October 1, 2005; 23(28): 6846 - 6853.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
B. S. Halpern, C. Schiepers, W. A. Weber, T. L. Crawford, B. J. Fueger, M. E. Phelps, and J. Czernin
Presurgical Staging of Non-small Cell Lung Cancer: Positron Emission Tomography, Integrated Positron Emission Tomography/CT, and Software Image Fusion
Chest, October 1, 2005; 128(4): 2289 - 2297.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
S. Erturan, M. Yaman, G. Aydin, I. Uzel, B. Musellim, and K. Kaynak
The Role of Whole-Body Bone Scanning and Clinical Factors in Detecting Bone Metastases in Patients With Non-small Cell Lung Cancer
Chest, February 1, 2005; 127(2): 449 - 454.
[Abstract] [Full Text] [PDF]

Home page
 The OncologistHome page
L. Schrevens, N. Lorent, C. Dooms, and J. Vansteenkiste
The Role of PET Scan in Diagnosis, Staging, and Management of Non-Small Cell Lung Cancer
Oncologist, November 1, 2004; 9(6): 633 - 643.
[Abstract] [Full Text] [PDF]

Home page
 ImagingHome page
D R Baldwin, J D Birchall, R H Ganatra, and K S Pointon
Evaluation of the solitary pulmonary nodule: clinical management, role of CT and nuclear medicine
Imaging, October 1, 2004; 16(1): 22 - 36.
[Abstract] [Full Text] [PDF]

Home page
 Clin. Cancer Res.Home page
H. Vesselle, E. Turcotte, L. Wiens, R. Schmidt, J. E. Takasugi, T. Lalani, E. Vallieres, and D. E. Wood
Relationship between Non-Small Cell Lung Cancer Fluorodeoxyglucose Uptake at Positron Emission Tomography and Surgical Stage with Relevance to Patient Prognosis
Clin. Cancer Res., July 15, 2004; 10(14): 4709 - 4716.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
R. C. Viney, M. J. Boyer, M. T. King, P. M. Kenny, C. A. Pollicino, J. M. McLean, B. C. McCaughan, and M. J. Fulham
Randomized Controlled Trial of the Role of Positron Emission Tomography in the Management of Stage I and II Non-Small-Cell Lung Cancer
J. Clin. Oncol., June 15, 2004; 22(12): 2357 - 2362.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F. C. Detterbeck, S. Falen, M. P. Rivera, J. S. Halle, and M. A. Socinski
Seeking a Home for a PET, Part 1: Defining the Appropriate Place for Positron Emission Tomography Imaging in the Diagnosis of Pulmonary Nodules or Masses
Chest, June 1, 2004; 125(6): 2294 - 2299.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
F. C. Detterbeck, S. Falen, M. P. Rivera, J. S. Halle, and M. A. Socinski
Seeking a Home for a PET, Part 2: Defining the Appropriate Place for Positron Emission Tomography Imaging in the Staging of Patients With Suspected Lung Cancer
Chest, June 1, 2004; 125(6): 2300 - 2308.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
E. M. Rohren, T. G. Turkington, and R. E. Coleman
Clinical Applications of PET in Oncology
Radiology, May 1, 2004; 231(2): 305 - 332.
[Abstract] [Full Text] [PDF]

Home page
 ChestHome page
D. Kahn, Y. Menda, K. Kernstine, D. Bushnell, K. McLaughlin, S. Miller, and K. Berbaum
The Utility of 99mTc Depreotide Compared With F-18 Fluorodeoxyglucose Positron Emission Tomography and Surgical Staging in Patients With Suspected Non-small Cell Lung Cancer
Chest, February 1, 2004; 125(2): 494 - 501.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
D. G. Pfister, D. H. Johnson, C. G. Azzoli, W. Sause, T. J. Smith, S. Baker Jr, J. Olak, D. Stover, J. R. Strawn, A. T. Turrisi, et al.
American Society of Clinical Oncology Treatment of Unresectable Non-Small-Cell Lung Cancer Guideline: Update 2003
J. Clin. Oncol., January 15, 2004; 22(2): 330 - 353.
[Full Text] [PDF]

Home page
 JNMHome page
G. W. Goerres, G. K. von Schulthess, and H. C. Steinert
Why Most PET of Lung and Head-and-Neck Cancer Will Be PET/CT
J. Nucl. Med., January 1, 2004; 45(90010): 66S - 71.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
C. E. Reed, D. H. Harpole, K. E. Posther, S. L. Woolson, R. J. Downey, B. F. Meyers, R. T. Heelan, H. A. MacApinlac, S.-H. Jung, G. A. Silvestri, et al.
Results of the American College of Surgeons Oncology Group Z0050 trial: the utility of positron emission tomography in staging potentially operable non-small cell lung cancer
J. Thorac. Cardiovasc. Surg., December 1, 2003; 126(6): 1943 - 1951.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
G. Antoch, J. Stattaus, A. T. Nemat, S. Marnitz, T. Beyer, H. Kuehl, A. Bockisch, J. F. Debatin, and L. S. Freudenberg
Non-Small Cell Lung Cancer: Dual-Modality PET/CT in Preoperative Staging
Radiology, November 1, 2003; 229(2): 526 - 533.
[Abstract] [Full Text] [PDF]

Home page
 Arch DermatolHome page
S. W. Fosko, W. Hu, T. F. Cook, and V. J. Lowe
Positron Emission Tomography for Basal Cell Carcinoma of the Head and Neck
Arch Dermatol, September 1, 2003; 139(9): 1141 - 1146.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
D. Lardinois, W. Weder, T. F. Hany, E. M. Kamel, S. Korom, B. Seifert, G. K. von Schulthess, and H. C. Steinert
Staging of Non-Small-Cell Lung Cancer with Integrated Positron-Emission Tomography and Computed Tomography
N. Engl. J. Med., June 19, 2003; 348(25): 2500 - 2507.
[Abstract] [Full Text] [PDF]

Home page
 JCOHome page
M. P. Mac Manus, R. J. Hicks, J. P. Matthews, A. McKenzie, D. Rischin, E. K. Salminen, and D. L. Ball
Positron Emission Tomography Is Superior to Computed Tomography Scanning for Response-Assessment After Radical Radiotherapy or Chemoradiotherapy in Patients With Non-Small-Cell Lung Cancer
J. Clin. Oncol., April 1, 2003; 21(7): 1285 - 1292.
[Abstract] [Full Text] [PDF]

Home page
 JNMHome page
E. V. Dizendorf, B. G. Baumert, G. K. von Schulthess, U. M. Lutolf, and H. C. Steinert
Impact of Whole-Body 18F-FDG PET on Staging and Managing Patients for Radiation Therapy
J. Nucl. Med., January 1, 2003; 44(1): 24 - 29.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
T. F. Hany, H. C. Steinert, G. W. Goerres, A. Buck, and G. K. von Schulthess
PET Diagnostic Accuracy: Improvement with In-Line PET-CT System: Initial Results
Radiology, November 1, 2002; 225(2): 575 - 581.
[Abstract] [Full Text] [PDF]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
H. Vesselle, J. M. Pugsley, E. Vallieres, and D. E. Wood
The impact of fluorodeoxyglucose F 18 positron-emission tomography on the surgical staging of non-small cell lung cancer
J. Thorac. Cardiovasc. Surg., September 1, 2002; 124(3): 511 - 519.
[Abstract] [Full Text] [PDF]

Home page
 RadiologyHome page
E. M. Kamel, G. W. Goerres, C. Burger, G. K. von Schulthess, and H. C. Steinert
Recurrent Laryngeal Nerve Palsy in Patients with Lung Cancer: Detection with PET-CT Image Fusion—Report of Six Cases
Radiology, July 1, 2002; 224(1): 153 - 156.
[Abstract] [Full Text]

Home page
 Eur Respir JHome page
N. Hollings and P. Shaw
Diagnostic imaging of lung cancer
Eur. Respir. J., April 1, 2002; 19(4): 722 - 742.
[Abstract] [Full Text] [PDF]

Home page
 Ann OncolHome page
E. Salminen and M. Mac Manus
FDG-PET imaging in the management of non-small-cell lung cancer
Ann. Onc., March 1, 2002; 13(3): 357 - 360.
[Abstract] [Full Text] [PDF]

Home page
 Eur Respir JHome page
J.F. Vansteenkiste
Imaging in lung cancer: positron emission tomography scan
Eur. Respir. J., February 1, 2002; 19(35_suppl): 49S - 60s.
[Abstract] [Full Text] [PDF]

Home page
 ThoraxHome page
G Laking and P Price
18-Fluorodeoxyglucose positron emission tomography (FDG-PET) and the staging of early lung cancer
Thorax, September 1, 2001; 56(90002): ii38 - 44.
[Full Text] [PDF]

Home page
 JNMHome page
S. S. Gambhir, J. Czernin, J. Schwimmer, D. H. S. Silverman, R. E. Coleman, and M. E. Phelps
A Tabulated Summary of the FDG PET Literature
J. Nucl. Med., May 1, 2001; 42(90050): 1S - 93.
[Full Text] [PDF]

Home page
 Eur Respir JHome page
J.F. Vansteenkiste and S.G. Stroobants
The role of positron emission tomography with 18F-fluoro-2-deoxy-D-glucose in respiratory oncology
Eur. Respir. J., April 1, 2001; 17(4): 802 - 820.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
R. M. Pieterman, J. W.G. van Putten, J. J. Meuzelaar, E. L. Mooyaart, W. Vaalburg, G. H. Koeter, V. Fidler, J. Pruim, and H. J.M. Groen
Preoperative Staging of Non-Small-Cell Lung Cancer with Positron-Emission Tomography
N. Engl. J. Med., July 27, 2000; 343(4): 254 - 261.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Roentgenol.Home page
J. J. Erasmus, H. P. McAdams, S. E. Rossi, P. C. Goodman, R. E. Coleman, and E. F. Patz
FDG PET of Pleural Effusions in Patients with Non--Small Cell Lung Cancer
Am. J. Roentgenol., July 1, 2000; 175(1): 245 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
K. H. Kernstine, W. Stanford, B. F. Mullan, N. P. Rossi, B. H. Thompson, D. L. Bushnell, K. A. McLaughlin, and J. A. Kern
PET, CT, and MRI with Combidex for mediastinal staging in non-small cell lung carcinoma
Ann. Thorac. Surg., September 1, 1999; 68(3): 1022 - 1028.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1998 by The Society of Thoracic Surgeons.