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Ann Thorac Surg 1998;66:455-461
© 1998 The Society of Thoracic Surgeons

Original articles: cardiovascular

Mechanical properties of human saphenous veins from normotensive and hypertensive patients

Veronica Milesi, PhDa, Alejandro Rebolledo, BSca, Felix Ayala Paredes, MDa,b, Nora Sanz, MDb, Juan Tommasi, MDb, Gustavo J. Rinaldi, MDa, Angela O. Grassi, MDa

a Department of Ciencias Biológicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, La Plata, Argentina
b Department of Hospital San Juan de Dios, Ministerio de Salud de la Provincia de Buenos Aires, La Plata, Argentina

Accepted for publication March 17, 1998.

Address reprint requests to Dr Grassi, CC 219, Correo Central, 1900 La Plata, Argentina
e-mail: (rinaldi{at}nahuel.biol.unlp.edu.ar)

Background. Different reactivities of saphenous vein grafts in hypertensive and normotensive patients could lead to differences in the postoperative patency of the grafts.

Methods. In saphenous vein rings isolated from remnants of aorta-coronary grafts obtained from hypertensive and normotensive patients we studied the length-tension relationship; response to high levels of potassium, norepinephrine, and epinephrine; and relaxation in response to calcium deprivation.

Results. The rings from hypertensive patients were stiffer and developed more force (grams force/grams weight) than the rings from normotensive subjects to 80 mmol/L potassium (59 ± 16 versus 25 ± 5, p < 0.05) and to 1 µmol/L norepinephrine (61 ± 8 versus 36 ± 7, p < 0.05), but not to 10 µmol/L epinephrine (57 ± 11 and 54 ± 11; not significant). The rings from hypertensive patients relaxed more slowly than those of the normotensive subjects in a calcium-free medium (time to half-relaxation of 976 ± 180 versus 548 ± 81 seconds; p < 0.05).

Conclusions. The saphenous vein from hypertensive patients is less distensible, slower to relax, and more reactive to at least two agonists. These differences could influence the graft’s patency and the clinical outcome.




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