| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1998;65:1645-1649
© 1998 The Society of Thoracic Surgeons
a Department of Anesthesiology, Duke Heart Center, Duke University Medical Center, Durham, North Carolina, USA
Accepted for publication February 1, 1998.
Address reprint requests to Dr Grocott, Duke University Medical Center, Box 3094, Durham, NC 27710
e-mail: (groco001{at}mc.duke.edu)
Background. The glial protein S100ß has been used to estimate cerebral damage in a number of clinical settings. The purpose of this investigation was to determine the correlation between cerebral microemboli and S100ß levels during cardiac operations.
Methods. Transcranial Doppler ultrasonography was used to measure emboli in the right middle cerebral artery. Emboli counts (n = 111) were divided into five time periods: (1) incision to aortic cannulation; (2) aortic cannulation to cross-clamp onset; (3) cross-clamp onset to cross-clamp release; (4) cross-clamp release to decannulation; and (5) decannulation to chest closure. The level of S100ß (n = 156) was measured at baseline, at the end of cardiopulmonary bypass, then 150 and 270 minutes after cross-clamp release.
Results. The level of S100ß correlated with age, cardiopulmonary bypass time, cross-clamp time, and number of emboli at time period 2. Although cardiopulmonary bypass time was univariately associated with S100ß level, it became nonsignificant in a multivariable model that included age and cross-clamp time.
Conclusions. The correlation of S100ß level with emboli measured during cannulation (time period 2) supports the hypothesis that cannulation is a high-risk time period for cerebral injury.
This article has been cited by other articles:
|
|
 |
|
  J. W. Hammon Extracorporeal Circulation: Perfusion System Card. Surg. Adult, January 1, 2008; 3(2008): 350 - 370. [Full Text]
|
|
|
|
 |
|
 R. C. Groom and Cardiovascular Disease Study Group A Systematic Approach to the Understanding and Redesigning of Cardiopulmonary Bypass Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2005; 9(2): 159 - 161. [Abstract] [PDF]
|
|
|
|
 |
|
 E. Iriz, F. Kolbakir, H. Akar, B. Adam, and H. T. Keceligil Comparison of Hydroxyethyl Starch and Ringer Lactate as a Prime Solution Regarding S-100{beta} Protein Levels and Informative Cognitive Tests in Cerebral Injury Ann. Thorac. Surg., February 1, 2005; 79(2): 666 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Motallebzadeh, R. Kanagasabay, M. Bland, J. C. Kaski, and M. Jahangiri S100 protein and its relation to cerebral microemboli in on-pump and off-pump coronary artery bypass surgery Eur. J. Cardiothorac. Surg., March 1, 2004; 25(3): 409 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Schoenburg, B. Kraus, A. Muehling, U. Taborski, H. Hofmann, G. Erhardt, S. Hein, M. Roth, P. R. Vogt, G. F. Karliczek, et al. The dynamic air bubble trap reduces cerebral microembolism during cardiopulmonary bypass J. Thorac. Cardiovasc. Surg., November 1, 2003; 126(5): 1455 - 1460. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ueno, Y. Iguro, H. Yamamoto, R. Sakata, Y. Kakihana, and K. Nakamura Serial measurement of serum S-100B protein as a marker of cerebral damage after cardiac surgery Ann. Thorac. Surg., June 1, 2003; 75(6): 1892 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. A. Hessel II and L. H. Edmunds Jr. Extracorporeal Circulation: Perfusion Systems Card. Surg. Adult, January 1, 2003; 2(2003): 317 - 338. [Full Text]
|
|
|
|
 |
|
 M. A. Ozatik, O. Tarcan, A. Kale, G. Askon, M. Balco, A. Undar, D. S. Kucukaksu, E. Sener, and O. Tasdemir Do S100{beta} protein level increases due to inflammation during cardiopulmonary bypass occur without any neurological deficit? Perfusion, September 1, 2002; 17(5): 335 - 338. [Abstract] [PDF]
|
|
|
|
|
|
G. S. Aldea, L. O. Soltow, W. L. Chandler, C. M. Triggs, C. R. Vocelka, G. I. Crockett, Y. T. Shin, W. E. Curtis, and E. D. Verrier Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits J. Thorac. Cardiovasc. Surg., April 1, 2002; 123(4): 742 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. B. Mark and M. F. Newman Protecting the Brain in Coronary Artery Bypass Graft Surgery JAMA, March 20, 2002; 287(11): 1448 - 1450. [Full Text] [PDF]
|
|
|
|
 |
|
 A. T. Tang, M. Devbhandari, and S. K Ohri Complete Myocardial Revascularization in Severe Arteriopathy Asian Cardiovasc Thorac Ann, December 1, 2001; 9(4): 315 - 317. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. W. Kim, D. C. Mariconda, G. Tellides, G. S. Kopf, M. L. Dewar, Z. Lin, and J. A. Elefteriades Single-clamp technique does not protect against cerebrovascular accident in coronary artery bypass grafting Eur. J. Cardiothorac. Surg., July 1, 2001; 20(1): 127 - 132. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Anderson, L.-O. Hansson, O. Nilsson, J. Liska, G. Settergren, and J. Vaage Increase in serum S100A1-B and S100BB during cardiac surgery arises from extracerebral sources Ann. Thorac. Surg., May 1, 2001; 71(5): 1512 - 1517. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. I. Dar, T. Gillott, F. Ciulli, and G. J. Cooper Single aortic cross-clamp technique reduces S-100 release after coronary artery surgery Ann. Thorac. Surg., March 1, 2001; 71(3): 794 - 796. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. S. Ali, M. Harmer, and R. Vaughan Serum S100 protein as a marker of cerebral damage during cardiac surgery Br. J. Anaesth., August 1, 2000; 85(2): 287 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Anderson, L.-O. Hansson, J. Liska, G. Settergren, and J. Vaage The effect of cardiotomy suction on the brain injury marker S100{beta} after cardiopulmonary bypass Ann. Thorac. Surg., March 1, 2000; 69(3): 847 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. W. Hammon Jr and D. Stump COMMENTARY: BIOCHEMICAL MARKERS OF BRAIN INJURY AFTER CARDIAC SURGERY J. Thorac. Cardiovasc. Surg., January 1, 2000; 119(1): 130 - 131. [Full Text] [PDF]
|
|
|
|
|
|
S. Westaby, K. Saatvedt, S. White, T. Katsumata, W. van Oeveren, N. K. Bhatnagar, S. Brown, and P. W. Halligan IS THERE A RELATIONSHIP BETWEEN SERUM S-100{beta} PROTEIN AND NEUROPSYCHOLOGIC DYSFUNCTION AFTER CARDIOPULMONARY BYPASS? J. Thorac. Cardiovasc. Surg., January 1, 2000; 119(1): 132 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Herrmann, A. D. Ebert, D. Tober, J. Hann, and C. Huth A contrastive analysis of release patterns of biochemical markers of brain damage after coronary artery bypass grafting and valve replacement and their association with the neurobehavioral outcome after cardiac surgery Eur. J. Cardiothorac. Surg., November 1, 1999; 16(5): 513 - 518. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Takahashi, A. Chamczuk, Y. Hong, and G. Jackowski Rapid and Sensitive Immunoassay for the Measurement of Serum S100B Using Isoform-specific Monoclonal Antibody Clin. Chem., August 1, 1999; 45(8): 1307 - 1311. [Full Text] [PDF]
|
|
|
|
|
|
R. E. Anderson, L.-O. Hansson, and J. Vaage Release of S100B during coronary artery bypass grafting is reduced by off-pump surgery Ann. Thorac. Surg., June 1, 1999; 67(6): 1721 - 1725. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
