| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Ann Thorac Surg 1998;65:1639-1644
© 1998 The Society of Thoracic Surgeons
a Division of Cardiothoracic Surgery, Department of Heart-Lung Diseases, University Hospital MAS, Malmö, Sweden
Accepted for publication January 26, 1998.
Address reprint requests to Dr Johnsson, Division of Cardiothoracic Surgery, Lund University Hospital, SE-221 85 Lund, Sweden
e-mail: (pelle.johnsson{at}medforsk.mas.lu.se)
Background. S100 protein has been suggested to be a serum marker for cerebral complications after cardiac operation and extracorporeal circulation. The aim of this study was to characterize the S100 release pattern after extracorporeal circulation in 515 consecutive patients undergoing coronary artery bypass grafting.
Methods. Clinical variables and outcome were prospectively registered. The cerebral outcome was determined by clinical examination. S100 was measured at the end of extracorporeal circulation, and after 5, 15, and 48 hours.
Results. After operation, 13 patients had stroke, 12 had delayed awakening, and 17 had encephalopathy. Early S100 release, immediately after extracorporeal circulation, was associated with age and perfusion time, but not with cerebral outcome. However, S100 release after 5 to 48 hours was associated with cerebral complications and risk factors for such outcome. Patients with stroke had higher S100 levels after 15 to 48 hours. A subset of patients with renal failure had overall higher S100 levels at 5 hours.
Conclusions. Early and late S100 release indicate different mechanisms for release and emphasizes the potential power of this new biochemical marker for cerebral damage.
This article has been cited by other articles:
|
|
 |
|
  P. D Raymond, M. Radel, M. J Ray, A. D Hinton-Bayre, and N. A Marsh Investigation of factors relating to neuropsychological change following cardiac surgery Perfusion, January 1, 2007; 22(1): 27 - 33. [Abstract] [PDF]
|
|
|
|
 |
|
 S. Dogan, T. Aybek, P. S. Risteski, F. Detho, A. Rapp, G. Wimmer-Greinecker, and A. Moritz Minimally Invasive Port Access Versus Conventional Mitral Valve Surgery: Prospective Randomized Study Ann. Thorac. Surg., February 1, 2005; 79(2): 492 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Iriz, F. Kolbakir, H. Akar, B. Adam, and H. T. Keceligil Comparison of Hydroxyethyl Starch and Ringer Lactate as a Prime Solution Regarding S-100{beta} Protein Levels and Informative Cognitive Tests in Cerebral Injury Ann. Thorac. Surg., February 1, 2005; 79(2): 666 - 671. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. I. Hall Serum S-100{beta} protein and postoperative neurological dysfunction - ready for prime time?/La proteine serique S-100{beta} et la dysfonction neurologique postoperatoire - correlation prete pour une large diffusion? Can J Anesth, August 1, 2004; 51(7): 645 - 648. [Full Text] [PDF]
|
|
|
|
|
|
M. Kanbak, F. Saricaoglu, A. Avci, T. Ocal, Z. Koray, and U. Aypar Propofol offers no advantage over isoflurane anesthesia for cerebral protection during cardiopulmonary bypass: a preliminary study of S-100{beta} protein levels: [L'anesthesie au propofol, compare a l'isoflurane, n'a pas d'avantage pour la protection cerebrale pendant la circulation extracorporelle : une etude preliminaire des niveaux de proteines S-100{beta}] Can J Anesth, August 1, 2004; 51(7): 712 - 717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Fazio, S. K. Bhudia, N. Marchi, B. Aumayr, and D. Janigro Peripheral detection of S100{beta} during cardiothoracic surgery: what are we really measuring? Ann. Thorac. Surg., July 1, 2004; 78(1): 46 - 52. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. R. Lynch, R. Blessing, W. D. White, H. P. Grocott, M. F. Newman, and D. T. Laskowitz Novel Diagnostic Test for Acute Stroke Stroke, January 1, 2004; 35(1): 57 - 63. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Ueno, Y. Iguro, H. Yamamoto, R. Sakata, Y. Kakihana, and K. Nakamura Serial measurement of serum S-100B protein as a marker of cerebral damage after cardiac surgery Ann. Thorac. Surg., June 1, 2003; 75(6): 1892 - 1897. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Marchi, V. Fazio, L. Cucullo, K. Kight, T. Masaryk, G. Barnett, M. Volgelbaum, M. Kinter, P. Rasmussen, M. R. Mayberg, et al. Serum Transthyretin Monomer as a Possible Marker of Blood-to-CSF Barrier Disruption J. Neurosci., March 1, 2003; 23(5): 1949 - 1955. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. K. Haddock, W. S. C. Poston, and J. E. Taylor Neurocognitive Sequelae Following Coronary Artery Bypass Graft: A Research Agenda for Behavioral Scientists Behav Modif, January 1, 2003; 27(1): 68 - 82. [Abstract] [PDF]
|
|
|
|
|
|
S. Dogan, K. Graubitz, T. Aybek, M. F. Khan, P. Kessler, A. Moritz, and G. Wimmer-Greinecker How safe is the port access technique in minimally invasive coronary artery bypass grafting? Ann. Thorac. Surg., November 1, 2002; 74(5): 1537 - 1543. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. A. Ozatik, O. Tarcan, A. Kale, G. Askon, M. Balco, A. Undar, D. S. Kucukaksu, E. Sener, and O. Tasdemir Do S100{beta} protein level increases due to inflammation during cardiopulmonary bypass occur without any neurological deficit? Perfusion, September 1, 2002; 17(5): 335 - 338. [Abstract] [PDF]
|
|
|
|
|
|
R. Ascione, S. Al-Ruzzeh, K. Amer, and G. D Angelini Subsystem organ function during coronary surgery Perfusion, July 1, 2002; 17(4): 295 - 303. [Abstract] [PDF]
|
|
|
|
 |
|
 G. S. Aldea, L. O. Soltow, W. L. Chandler, C. M. Triggs, C. R. Vocelka, G. I. Crockett, Y. T. Shin, W. E. Curtis, and E. D. Verrier Limitation of thrombin generation, platelet activation, and inflammation by elimination of cardiotomy suction in patients undergoing coronary artery bypass grafting treated with heparin-bonded circuits J. Thorac. Cardiovasc. Surg., April 1, 2002; 123(4): 742 - 755. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R I. Johnson, M. A Fox, A. Grayson, M. Jackson, and B. M Fabri Should we rely on nasopharyngeal temperature during cardiopulmonary bypass? Perfusion, March 1, 2002; 17(2): 145 - 151. [Abstract] [PDF]
|
|
|
|
 |
|
 L. V. C. Portela, J. C. T. Brenol, R. Walz, M. Bianchin, A. B. L. Tort, U. P. Canabarro, S. Beheregaray, J. A. Marasca, R. M. Xavier, E. C. Neto, et al. Serum S100B Levels in Patients with Lupus Erythematosus: Preliminary Observation Clin. Vaccine Immunol., January 1, 2002; 9(1): 164 - 166. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. W. Bottiger, S. Mobes, R. Glatzer, H. Bauer, A. Gries, P. Bartsch, J. Motsch, and E. Martin Astroglial Protein S-100 Is an Early and Sensitive Marker of Hypoxic Brain Damage and Outcome After Cardiac Arrest in Humans Circulation, June 5, 2001; 103(22): 2694 - 2698. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. A. LeMaire, J. K. Bhama, Z. C. Schmittling, P. J. Oberwalder, C. Koksoy, S. A. Raskin, P. E. Curling, and J. S. Coselli S100{beta} correlates with neurologic complications after aortic operation using circulatory arrest Ann. Thorac. Surg., June 1, 2001; 71(6): 1913 - 1919. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. Kislinger, N. Tanji, T. Wendt, W. Qu, Y. Lu, L. J. Ferran Jr, A. Taguchi, K. Olson, L. Bucciarelli, M. Goova, et al. Receptor for Advanced Glycation End Products Mediates Inflammation and Enhanced Expression of Tissue Factor in Vasculature of Diabetic Apolipoprotein E-Null Mice Arterioscler. Thromb. Vasc. Biol., June 1, 2001; 21(6): 905 - 910. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jonsson, P. Johnsson, M. Birch-Iensen, C. Alling, S. Westaby, and S. Blomquist S100B as a predictor of size and outcome of stroke after cardiac surgery Ann. Thorac. Surg., May 1, 2001; 71(5): 1433 - 1437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Svenmarker, E. Sandstrom, T. Karlsson, S. Haggmark, E. Jansson, M. Appelblad, R. Lindholm, and T. Aberg Neurological and general outcome in low-risk coronary artery bypass patients using heparin coated circuits Eur. J. Cardiothorac. Surg., January 1, 2001; 19(1): 47 - 53. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Herrmann, P. Vos, M. T. Wunderlich, C. H. M. M. de Bruijn, and K. J. B. Lamers Release of Glial Tissue-Specific Proteins After Acute Stroke : A Comparative Analysis of Serum Concentrations of Protein S-100B and Glial Fibrillary Acidic Protein Stroke, November 1, 2000; 31(11): 2670 - 2677. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Masetti and N. T. Kouchoukos S-100{beta} protein: Yet uncertain role as a marker of cerebral injury in cardiac surgery J. Thorac. Cardiovasc. Surg., October 1, 2000; 120(4): 830 - 831. [Full Text]
|
|
|
|
 |
|
 M. S. Ali, M. Harmer, and R. Vaughan Serum S100 protein as a marker of cerebral damage during cardiac surgery Br. J. Anaesth., August 1, 2000; 85(2): 287 - 298. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Herrmann, A. D. Ebert, I. Galazky, M. T. Wunderlich, W. S. Kunz, and C. Huth Neurobehavioral Outcome Prediction After Cardiac Surgery : Role of Neurobiochemical Markers of Damage to Neuronal and Glial Brain Tissue Stroke, March 1, 2000; 31(3): 645 - 650. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Westaby, K. Saatvedt, S. White, T. Katsumata, W. van Oeveren, N. K. Bhatnagar, S. Brown, and P. W. Halligan IS THERE A RELATIONSHIP BETWEEN SERUM S-100{beta} PROTEIN AND NEUROPSYCHOLOGIC DYSFUNCTION AFTER CARDIOPULMONARY BYPASS? J. Thorac. Cardiovasc. Surg., January 1, 2000; 119(1): 132 - 137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Jonsson, P. Johnsson, C. Alling, M. Backstrom, C. Bergh, and S. Blomquist S100{beta} after coronary artery surgery: release pattern, source of contamination, and relation to neuropsychological outcome Ann. Thorac. Surg., December 1, 1999; 68(6): 2202 - 2208. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| ANN THORAC SURG | ASIAN CARDIOVASC THORAC ANN | EUR J CARDIOTHORAC SURG |
| J THORAC CARDIOVASC SURG | ICVTS | ALL CTSNet JOURNALS |
