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Ruggero De Paulis
Luisa Colagrande
Francesco Seddio
Marco Piciché
Carlo Bassano
Luigi Chiariello
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Ann Thorac Surg 1998;65:1617-1620
© 1998 The Society of Thoracic Surgeons

Original articles: cardiovascular

Levels of Troponin I and Cardiac Enzymes After Reinfusion of Shed Blood in Coronary Operations

Ruggero De Paulis, MDa, Luisa Colagrande, MDa, Francesco Seddio, MDa, Marco Piciché, MDa, Alfonso Penta de Peppo, MDa, Carlo Bassano, MDa, Fabrizio Tomai, MDa, Luigi Chiariello, MDa

a Cattedra di Cardiochirurgia, Università di Roma Tor Vergata, Roma, Italy

Accepted for publication January 16, 1998.

Address reprint requests to Dr De Paulis, Cattedra di Cardiochirurgia, Università di Roma, Tor Vergata, European Hospital, via Portuense 700, 00149 Rome, Italy

Background. Reinfusion of shed blood after coronary artery bypass grafting might increase the levels of cardiac enzymes with consequent difficulties in the diagnosis of perioperative myocardial infarction.

Methods. Thirty consecutive patients undergoing coronary artery bypass grafting who bled at least 400 mL within the first 4 hours after operation underwent reinfusion of shed blood. Thirty consecutive patients who were not autotransfused served as control. All patients underwent enzyme determination (total creatine kinase, MB fraction, lactate dehydrogenase, and troponin I) in the shed blood and in circulating blood preoperatively, at arrival in the intensive care unit, and 6, 24, and 48 hours after operation.

Results. The shed blood contained significantly higher concentration of cardiac enzymes than the circulating blood at all time intervals (p = 0.0001). The levels of creatine kinase, its MB fraction, and lactate dehydrogenase in circulating blood were significantly elevated in patients receiving autotransfusion up to 24 hours after autotransfusion. The blood levels of troponin I were not significantly different between the two group of patients at all time points. The percent fraction of MB did not increase after autotransfusion.

Conclusions. The measurement of cardiac troponin I is a useful marker for the diagnosis of perioperative myocardial infarction in patients undergoing transfusion of shed blood after coronary operation.






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