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Markus Furrer
Didier Lardinois
Ulrich Althaus
Michael E. Burt
Hans-Beat Ris
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Ann Thorac Surg 1998;65:1523-1528
© 1998 The Society of Thoracic Surgeons

Original articles: general thoracic

Cytostatic Lung Perfusion by Use of an Endovascular Blood Flow Occlusion Technique

Markus Furrer, MDa, Didier Lardinois, MDa, Wolfgang Thormann, PhDa, Hans-Jörg Altermatt, MDa, Daniel Betticher, MDa, Jürgen Triller, MDa, Daniel Mettler, DVMa, Ulrich Althaus, MDa, Michael E. Burt, MD, PhDa,1, Hans-Beat Ris, MDa

a Department of Thoracic and Cardiovascular Surgery, University of Berne, Berne, Switzerland

Accepted for publication January 2, 1998.

Address reprint requests to Dr Furrer, Thoracic and Vascular Surgery Unit, Kantonsspital, CH-7000 Chur, Switzerland
e-mail: (markus.furrer{at}ksc.chur.ch)

Background. Different modalities of cytostatic lung perfusion were compared regarding plasma and tissue drug concentrations to assess the efficacy of an endovascular blood flow occlusion technique.

Methods. A cytostatic lung perfusion study with doxorubicin hydrochloride was performed on large white pigs (n = 12). Plasma and tissue concentrations of doxorubicin were compared for isolated lung perfusion with open cannulation (ILP), blood flow occlusion perfusion with open cannulation of the pulmonary artery alone (BFO), and intravenous drug administration (IV). In a fourth group, thoracotomy-free BFO perfusion was performed by endovascular balloon catheterization of the pulmonary artery (endovascular BFO). The 3 animals in this group were used to compare the doxorubicin-perfused pulmonary tissue with the contralateral nonperfused lobes after 1 month.

Results. The mean lung tissue doxorubicin concentration at the end of perfusion was 19.8 ± 1.6 µg/g after ILP, 27.6 ± 2.2 µg/g after BFO (p = not significant), and 3.0 ± 0.8 µg/g after IV perfusion (p < 0.01). Whereas doxorubicin was not detectable in the plasma in the ILP group, concentrations ranged from not detectable to 0.44 µg/mL in the BFO group and from 0.31 to 0.84 µg/mL in the IV group (p < 0.05). Mean myocardial tissue concentration was not significantly different after BFO than IV perfusion (1.1 ± 0.5 µg/g and 1.8 ± 0.1 µg/g, respectively). In the endovascular BFO group, balloon-blocked pulmonary artery perfusion was successfully performed in all animals, and after 1 month, lung tissue showed no cytostatic-induced histologic changes.

Conclusions. Compared with ILP, BFO cytostatic lung perfusion produced an insignificantly higher lung-tissue concentration, corresponding to a sixfold to ninefold higher level than after IV perfusion. Plasma drug levels during BFO perfusion were lower than during IV perfusion. Endovascular BFO may be a promising technique for repeated cytostatic lung perfusion.






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