ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Y. John Gu
Massimo A. Mariani
Jan G. Grandjean
Piet W. Boonstra
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gu, Y. J.
Right arrow Articles by Boonstra, P. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gu, Y. J.
Right arrow Articles by Boonstra, P. W.

Ann Thorac Surg 1998;65:420-424
© 1998 The Society of Thoracic Surgeons

Original Articles: Cardiovascular

Reduction of the Inflammatory Response in Patients Undergoing Minimally Invasive Coronary Artery Bypass Grafting

Y. John Gu, MD, PhD, Massimo A. Mariani, MD, PhD, Willem van Oeveren, PhD, Jan G. Grandjean, MD, PhD, Piet W. Boonstra, MD, PhD

Department of Cardiothoracic Surgery, Thorax Center, University Hospital, Groningen, the Netherlands

Accepted for publication August 5, 1997.

Dr Boonstra, Department of Cardiothoracic Surgery, University Hospital Groningen, Hanzeplein 1, 9700 RB Groningen, the Netherlands.

Background. The aim of this prospective study was to determine whether the inflammation-associated clinical morbidity as well as the subclinical markers of the inflammatory response are reduced in patients who undergo minimally invasive coronary artery bypass grafting without cardiopulmonary bypass.

Methods. From June 1995 to June 1996, 62 consecutive patients with isolated stenosis of the left anterior descending coronary artery were assigned randomly to two groups: 31 patients underwent minimally invasive coronary artery bypass grafting and 31 patients underwent conventional coronary artery bypass grafting with cardiopulmonary bypass. In a subgroup of 10 patients in each group, subclinical markers were measured to determine the level of the inflammatory response generated during the operation.

Results. In the group that underwent minimally invasive coronary artery bypass grafting, leukocyte elastase, platelet ß-thromboglobulin, and complement C3a were unchanged at the end of the procedure compared with their baseline concentrations, whereas these inflammatory markers were increased significantly in the group that underwent conventional coronary artery bypass grafting with cardiopulmonary bypass. The patients who underwent minimally invasive coronary artery bypass grafting had a shorter duration of operation (104 ± 28 versus 140 ± 28 minutes; p < 0.01), less blood loss (312 ± 167 versus 788 ± 365 mL; p < 0.01), shorter ventilatory support (7.7 ± 4.1 versus 12.9 ± 3.4 hours; p < 0.01), and a shorter postoperative hospital stay (4.4 ± 1.7 versus 7.7 ± 2.6 days; p < 0.01) than the patients who underwent the conventional procedure.

Conclusions. These data suggest that patients who undergo minimally invasive coronary artery bypass grafting have a significant reduction in the systemic inflammatory response, postoperative morbidity, and hospital stay compared with patients who undergo conventional coronary artery bypass grafting with cardiopulmonary bypass.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1998 by The Society of Thoracic Surgeons.