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Frank A. Pigula
Bartley P. Griffith
Marco A. Zenati
Robert J. Keenan
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Ann Thorac Surg 1997;64:1630-1634
© 1997 The Society of Thoracic Surgeons

Original Articles: General Thoracic

Lung Transplantation for Respiratory Failure Resulting From Systemic Disease

Frank A. Pigula, MD, Bartley P. Griffith, MD, Marco A. Zenati, MD, James H. Dauber, MD, Samuel A. Yousem, MD, Robert J. Keenan, MD

Division of Cardiothoracic Surgery, Presbyterian University Hospital, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania

Accepted for publication June 26, 1997.

Background. Lung transplantation for pulmonary failure resulting from systemic disease is controversial. We reviewed our transplant experience in patients with sarcoidosis, scleroderma, lymphangioleiomyomatosis, and graft-versus-host disease.

Methods. This retrospective review examined the outcome of 23 patients who underwent pulmonary transplantation for these systemic diseases. Group 1 included 15 patients with pulmonary hypertension who underwent transplantation (9 for sarcoidosis, 6 for scleroderma), and group 2 included 8 patients with normal pulmonary artery pressures who underwent transplantation (5 for lymphangioleiomyomatosis, 3 for graft-versus-host disease). The incidences of infection and rejection, pulmonary function, and survival were measured and compared with those of patients who underwent transplantation for isolated pulmonary disease.

Results. Although there were no differences in the rate of infection between patients who underwent transplantation for systemic versus isolated disease, patients with pulmonary hypertension who underwent transplantation for systemic disease had significantly lower rates of rejection. Four patients with sarcoidosis and 2 with lymphangioleiomyomatosis demonstrated recurrence in the allograft. Survival was similar between patients who underwent transplantation for systemic versus isolated disease.

Conclusions. Patients with respiratory failure resulting from these systemic diseases can undergo transplantation with outcomes comparable to those obtained in patients who undergo transplantation for isolated pulmonary disease.






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Copyright © 1997 by The Society of Thoracic Surgeons.