ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Full Text
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Author home page(s):
Edward P. Chen
Hartmuth B. Bittner
Peter Van Trigt, III
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chen, E. P.
Right arrow Articles by Van Trigt, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chen, E. P.
Right arrow Articles by Van Trigt, P., III

Ann Thorac Surg 1997;63:806-813
© 1997 The Society of Thoracic Surgeons

Original Article: General Thoracic

Pulmonary Hemodynamics and Blood Flow Characteristics in Chronic Pulmonary Hypertension

Edward P. Chen, MD, Hartmuth B. Bittner, MD, PhD, Damian M. Craig, MS, R. Duane Davis, Jr, MD, Peter Van Trigt, III, MD

Division of Cardiovascular and Thoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina

Accepted for publication October 28, 1996.

Background. Lung transplantation is now an acceptable form of therapy for pulmonary hypertension, but controversy remains regarding the most appropriate surgical procedure. In this study, the changes in pulmonary vascular mechanics occurring in the setting of pulmonary hypertension were investigated using an adult canine model of monocrotaline pyrrole–induced pulmonary hypertension.

Methods. Animals underwent pulmonary artery catheterization to measure right heart pressures before and 8 weeks after injection of either 3 mg/kg of monocrotaline pyrrole (n = 8) or placebo (n = 8). Eight weeks after injection, hearts underwent instrumentation with an ultrasonic flow probe and micromanometers. Harmonic derivation of functional data was achieved with Fourier analysis.

Results. Significant increases in mean pulmonary artery pressure and pulmonary vascular resistance were observed after monocrotaline pyrrole injection. There was no significant difference in pulmonary blood flow. However, significant increases in input resistance and right ventricular hydraulic power with significant decreases in transpulmonary efficiency were observed.

Conclusions. Pulmonary hypertension causes significant alterations in pulmonary hemodynamics. Pulmonary blood flow is maintained by a significant increase in total power but with a significant decrease in transpulmonary efficiency. This adult canine model of pulmonary hypertension provides a useful means by which to evaluate surgical options of lung transplantation for improving pulmonary hemodynamics in the setting of chronic pulmonary hypertension.




This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
Y. Takami and H. Ina
Relation of intraoperative flow measurement with postoperative quantitative angiographic assessment of coronary artery bypass grafting
Ann. Thorac. Surg., October 1, 2001; 72(4): 1270 - 1274.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
E. P. Chen, S. A. Akhter, H. B. Bittner, W. J. Koch, R. D. Davis, and P. Van Trigt III
Molecular and functional mechanisms of right ventricular adaptation in chronic pulmonary hypertension
Ann. Thorac. Surg., April 1, 1999; 67(4): 1053 - 1058.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1997 by The Society of Thoracic Surgeons.