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Ann Thorac Surg 1995;60:1698-1703
© 1995 The Society of Thoracic Surgeons

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Original Articles: Cardiovascular

Different Effects of an Adenosine A₁ Analogue and Ischemic Preconditioning in Isolated Rabbit Hearts

Department of Surgery, University of Wisconsin School of Medicine, Madison, Wisconsin

Accepted for publication July 18, 1995.

Background. Ischemic preconditioning reduces infarct size, but its effects on postischemic function are variable. Adenosine, which is thought to play a role in ischemic preconditioning, reduces both infarct size and postischemic dysfunction. The purpose of this study was to compare the cardioprotective effects of ischemic preconditioning and an adenosine A₁ receptor agonist on recovery of function and infarct size in isolated rabbit hearts.

Methods. Krebs buffer-perfused hearts (at least 7 per group) were subjected to 60 minutes of global ischemia (37°C) and 60 minutes of reperfusion. Ventricular function was assessed by measuring left ventricular developed pressure, and infarct size (percentage of the left ventricle) was determined by tetrazolium staining.

Results. Control hearts exhibited 34% ± 6% infarct size and 56% ± 4% recovery of preischemic left ventricular developed pressure. Ischemic preconditioning reduced infarct size to 13% ± 1% but had no effect on recovery of function (65% ± 5%). Hearts treated with the adenosine A₁ agonist R-phenylisopropyladenosine for 5 minutes immediately before ischemia exhibited both reduced infarct size (10% ± 2%) and enhanced postischemic recovery of left ventricular developed pressure (86% ± 3%). Termination of the R-phenylisopropyladenosine treatment before ischemia eliminated its beneficial effects. The adenosine A₁ receptor antagonist DPCPX blocked both of the effects of R-phenylisopropyladenosine but did not block ischemic preconditioning.

Conclusions. These results demonstrate fundamental differences between the cardioprotective effects of adenosine A₁ receptor activation and ischemic preconditioning.

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Esophageal Surgery: Edited by F. Griffith Pearson, Jean Deslauriers, Robert J. Ginsberg, Clement A. Hiebert, Martin F. McKneally, and Harold C. Urschel, Jr New York, Churchill Livingstone, 1995 825 pp, illustrated, $159.95

Mark K. Ferguson
Ann. Thorac. Surg. 1995 60: 1703. [Extract] [Full Text]

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