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Ann Thorac Surg 1995;60:958-962
© 1995 The Society of Thoracic Surgeons

Original Articles: General Thoracic

Lung Preservation Threshold in a Compromised Septic Lung Injury Model

Shigeyuki Sasaki, MD, PhD, James D. McCully, PhD, John D. Palombo, ScD, R. Armour Forse, MD, PhD, Joseph LoCicero, III, MD

Section of General Thoracic Surgery, Department of Surgery, Harvard Medical School, New England Deaconess Hospital, Boston, Massachusetts

Accepted for publication May 12, 1995.

Background. Discrepancy between clinical and research works in lung transplantation could be due to differences between compromised clinical donor lungs and intact research lungs. The purpose of this laboratory study was to produce compromised lungs to compare with normal ones.

Methods. Sprague-Dawley rats were continuously infused with lipopolysaccharide (5 mg/kg) for 24 hours before organ harvest. Lungs were stored in University of Wisconsin solution at 4°C for the following period: group 1: intact lungs, no storage (n = 12); group 2: septic lungs, no storage (n = 6); group 3: septic lungs for 6 hours (n = 5); and group 4: septic lungs for 12 hours (n = 5). All lungs were reperfused for 2 hours with venous blood using an isolated, pulsatile perfused lung system.

Results. Experimental variables were comparable between groups 1, 2, and 3. All septic lungs stored for 12 hours (group 4) failed within 1 hour of perfusion.

Conclusions. These results indicate that compromised lungs with septic injury functioned at near control levels after 6 hours of preservation. Six hours may be a safe limit for human donor lungs, all of which are compromised in some way by the time of harvest.


Related Article

Invited Commentary
Richard J. Novick
Ann. Thorac. Surg. 1995 60: 962-963. [Extract] [Full Text]



This article has been cited by other articles:


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 Ann. Thorac. Surg.Home page
R. J. Novick, K. E. Gehman, I. S. Ali, and J. Lee
Lung Preservation: The Importance of Endothelial and Alveolar Type II Cell Integrity
Ann. Thorac. Surg., July 1, 1996; 62(1): 302 - 314.
[Abstract] [Full Text]


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