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Ann Thorac Surg 1995;60:78-82
© 1995 The Society of Thoracic Surgeons

Ventricular Effluent of Retrograde Cardioplegia in Human Hearts Has Traversed Capillary Beds

Division of Cardiothoracic Surgery, Department of Surgery, University of California, Los Angeles, Medical Center, Los Angeles, California

Background:. In human hearts, as much as two thirds of retrograde cardioplegia is shunted through thebesian and arteriosinusoidal channels into the ventricular cavities. This ventricular effluent is believed to have bypassed the myocardial capillary beds and is therefore considered nonnutritive. Methods:. To test this hypothesis, we studied the explanted hearts from 9 cardiac transplant recipients with the diagnosis of idiopathic cardiomyopathy. These hearts were arrested in situ with cold blood cardioplegia and excised with the coronary sinus intact. The left and right coronary ostia and the coronary sinus then were cannulated. Colored microspheres (15 ± 5 µm) mixed in 37°C blood cardioplegia were administered through the coronary sinus at a pressure of 30 to 40 mm Hg. Effluents from the coronary arteries and ventricular chambers were collected and analyzed for microsphere concentration. Results:. Approximately 80% of retrograde cardioplegia solution was recovered in the ventricular chambers. Nearly 40% of this ventricular chambers effluent had traversed capillary beds and, thus, we believe has nutritive properties. Almost all of the coronary artery effluent of retrograde cardioplegia solution had traversed capillary beds. The total nutritive fraction of retrograde warm blood cardioplegia in this explanted human heart model was approximately 55%. Conclusions:. These findings suggest that the ventricular chamber effluent of retrograde blood cardioplegia contributes to the metabolic homeostasis of the arrested human heart.

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Discussion
Ann. Thorac. Surg. 1995 60: 82-83. [Extract] [Full Text]

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