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The Annals of Thoracic Surgery, Vol 58, 1316-1318, Copyright © 1994 by The Society of Thoracic Surgeons

ARTICLES

Tolerance to experimental cardiac allografts produced by neonatal intrathymic injection of donor cells

GM Kline, Z Shen, M Mohiuddin, S Rostami and VJ DiSesa
Division of Cardiothoracic Surgery, Medical College of Pennsylvania, Philadelphia 19129.

Intrathymic inoculation of allogeneic cells after systemic administration of antilymphocyte serum in adult experimental animals has produced donor-specific tolerance to cardiac allografts. We investigated whether thymic injection of allogeneic cells without antilymphocyte serum in neonatal Lewis rats (day 1 of life) with immature immune systems also produced tolerance to cardiac grafts. Intrathymic or intraperitoneal injection of 5 x 10(7) Lewis (control) or Lewis-Brown Norway (allogeneic) spleen cells in Lewis neonates was followed by heterotopic cardiac transplantation using Lewis, Lewis- Brown Norway, or Wistar Furth (third-party allograft) hearts at 6 to 8 weeks of age. Graft survival was prolonged with both intraperitoneal and intrathymic allogeneic cells. Recipients of cells by the intrathymic route had longer graft survival, and 2 of 5 animals achieved permanent graft acceptance (longer than 100 days). As expected, Lewis isografts survived indefinitely, whereas third-party Wistar Furth allografts were rejected in the usual time frame. Intrathymic introduction of allogeneic cells in a neonatal recipient with an immature immune system can produce donor-specific tolerance to a subsequent graft without the need for a systemic immunosuppression regimen, even transiently.


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D. Y. Wu and I. Goldschneider
Tolerance to Cyclosporin A-Induced Autologous Graft-Versus-Host Disease Is Mediated by a CD4+CD25+ Subset of Recent Thymic Emigrants
J. Immunol., June 15, 2001; 166(12): 7158 - 7164.
[Abstract] [Full Text] [PDF]


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