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The Annals of Thoracic Surgery, Vol 58, 961-971, Copyright © 1994 by The Society of Thoracic Surgeons
N Hayashida, JS Ikonomidis, RD Weisel, T Shirai, J Ivanov, SM Carson, MK Mohabeer, LC Tumiati and DA Mickle
Seventy-two patients undergoing coronary artery bypass grafting were
randomized to receive cold (8 degrees C) antegrade or retrograde, tepid (29
degrees C) antegrade or retrograde, or warm (37 degrees C) antegrade or
retrograde blood cardioplegia (n = 12 in each group). Myocardial oxygen
utilization as well as lactate and acid metabolism were assessed
intraoperatively and cardiac function was assessed postoperatively.
Myocardial oxygen consumption and anaerobic lactate release were greatest
during warm, intermediate during tepid, and least during cold cardioplegic
arrest. Myocardial oxygen consumption and lactate release were
underestimated during retrograde cardioplegia because of contamination of
aortic root samples. Warm retrograde and tepid retrograde cardioplegia
resulted in greater lactate and acid washout with reperfusion. Left
ventricular stroke work indices were greater after warm antegrade and tepid
antegrade cardioplegia than after cold antegrade cardioplegia, and right
ventricular stroke work indices were greatest after warm antegrade
cardioplegia. Warm antegrade cardioplegia increased aerobic metabolism
during and after cardioplegia and preserved left and right ventricular
function. Tepid antegrade cardioplegia reduced anaerobic lactate and acid
release during arrest and preserved cardiac function.
ARTICLES
The optimal cardioplegic temperature
Department of Clinical Biochemistry, Toronto Hospital, Ontario, Canada.
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