HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Goldstein, A. H. Articles by Clark, R. E. Search for Related Content PubMed PubMed Citation Articles by Goldstein, A. H. Articles by Clark, R. E.

The Annals of Thoracic Surgery, Vol 58, 1018-1024, Copyright © 1994 by The Society of Thoracic Surgeons

ARTICLES

Predictable reduction in left ventricular stroke work and oxygen utilization with an implantable centrifugal pump

AH Goldstein, JJ Pacella and RE Clark
Cardiovascular and Pulmonary Research Center, Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania 15212.

Previous investigations with roller pumps and pneumatic pulsatile assist devices have demonstrated that nearly complete capture of normal left ventricular end-diastolic volume was necessary for appreciable reductions in oxygen consumption and stroke work. We tested the hypothesis that a centrifugal pump would decrease left ventricular stroke work and oxygen consumption as a function of pump flow. Ten sheep (35 to 50 kg) were instrumented and placed on left atrium-to- descending aorta bypass with a small, lightweight (112 g), implantable centrifugal pump. The relations between pump flow as a percent of cardiac output (% bypass), left ventricular stroke work, and oxygen consumption were studied. Left ventricular stroke work was calculated from the pressure-volume loops obtained with micromanometer and conductance catheters and was indexed per 100 g of left ventricular wet weight. Oxygen consumption was calculated from left main coronary artery blood flow and the arterial-coronary sinus oxygen content difference, normalized to 100 g of left ventricular wet weight and a heart rate of 100 beats/min. Measurements were made in stepwise increments of pump flow from zero to the maximum obtainable and then reversed in similar decrements. Analyses were made for 27 complete runs. Our data demonstrate that reductions in left ventricular stroke work and oxygen consumption were achieved from zero to maximal bypass. There was an approximate 66% and 50% reduction in left ventricular stroke work and oxygen consumption, respectively, at 60% bypass.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				S. Kono, K. Nishimura, T. Nishina, S. Yuasa, K. Ueyama, C. Hamada, T. Akamatsu, and M. Komeda Autosynchronized systolic unloading during left ventricular assist with a centrifugal pump J. Thorac. Cardiovasc. Surg., February 1, 2003; 125(2): 353 - 360. [Abstract] [Full Text] [PDF]

				E. B. Savage, R. E. Clark, W. P. Griffin, S. A. Davis, S. Hughson, C. J. Conway, and G. J. Magovern Sr The AB-180 circulatory support system: summary of development and plans for phase I clinical trial Ann. Thorac. Surg., August 1, 1999; 68(2): 768 - 774. [Abstract] [Full Text] [PDF]

				R. E. Clark, A. H. Goldstein, J. J. Pacella, R. A. Walters, F. W. Moeller, G. R. Cattivera, S. Davis, and G. J. Magovern Sr Small, Low-Cost Implantable Centrifugal Pump for Short-Term Circulatory Assistance Ann. Thorac. Surg., January 1, 1996; 61(1): 452 - 456. [Abstract] [Full Text]