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The Annals of Thoracic Surgery, Vol 58, 833-835, Copyright © 1994 by The Society of Thoracic Surgeons

ARTICLES

Use of glutaraldehyde solution in the treatment of acute aortic dissections

YF Chen, SH Chou, CC Chiu, YT Lin and HJ Wang
Department of Surgery, Kaohsiung Medical College, Taiwan.

We report on a promising method for toughening and strengthening the fragile aortic wall that involves the direct application of a 25% glutaraldehyde solution and that has proved to be both technically simple and safe. The operation was successfully employed in 5 patients with acute aortic dissections, 3 with a Stanford type A and 2 with a type B dissection. Histologic examination of the glutaraldehyde-treated portions of the aortic wall showed no detectable difference between them and the sections of untreated aortic wall. All patients survived the operation. The duration of follow-up ranged from 9 to 31 months (mean, 14.0 months). All 5 patients were in good condition at the time of the last follow-up. The preliminary results indicate that the use of a 25% glutaraldehyde solution to strengthen the aortic wall during operations for the repair of acute aortic dissections, regardless of whether they are type A or type B, may reduce the incidence of catastrophic perioperative bleeding and promote favorable results.