HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sawyer, R. W. Articles by Benfield, J. R. Search for Related Content PubMed PubMed Citation Articles by Sawyer, R. W. Articles by Benfield, J. R.

The Annals of Thoracic Surgery, Vol 56, 74-78, Copyright © 1993 by The Society of Thoracic Surgeons

ARTICLES

Regression of bronchial epithelial cancer in hamsters

RW Sawyer, WG Hammond, RL Teplitz and JR Benfield
Department of Surgery, University of California Davis School of Medicine, Sacramento.

For bronchogenic carcinoma, if and when the sequential process of carcinogenesis is reversible is fundamental to chemoprevention research. In our hamster model, focally originating non-small cell lung carcinoma (NSCLC) develops via a reproducible sequential process of carcinogenesis by 180 days after endobronchial sustained-release implants (SRIs) of 10% benzo(a)pyrene. In this study, 114 hamsters received removable 10% benzo(a)pyrene SRIs. Short-term controls were sacrificed in 3 groups at 50, 65, and 80 days after SRI placement. Three experimental groups had SRIs removed at 50, 65, and 80 days after placement, and sacrifice was delayed until 100 to 180 days later. Long- term controls retained SRIs until sacrifice at 180 or 240 days after SRI placement. All long-term controls had NSCLC. Preneoplastic change was more common in 50- and 65-day controls, as compared with hamsters with equal duration of SRI exposure whose sacrifice was delayed until 100 to 180 days after SRI removal (p < 0.05). The 56% incidence of early NSCLC in hamsters sacrificed after 80 days of SRI exposure decreased to 5% in hamsters that had delayed sacrifice after SRI removal after 80 days of exposure. At the 10% benzo(a)pyrene dose used, hamster bronchial epithelium requires more than 80 days of continuous exposure to become irreversibly committed to NSCLC uniformly. Microinvasive NSCLC in hamsters often regresses, and it is not necessarily a precursor of overt invasive cancer. The removable SRI model provides new opportunities to evaluate chemoprevention of NSCLC and the related molecular-genetic control mechanisms.

This article has been cited by other articles:

				B. D. Vincent, M. Fraig, and G. A. Silvestri A Pilot Study of Narrow-Band Imaging Compared to White Light Bronchoscopy for Evaluation of Normal Airways and Premalignant and Malignant Airways Disease Chest, June 1, 2007; 131(6): 1794 - 1799. [Abstract] [Full Text] [PDF]

				D. Moro-Sibilot, F. Fievet, M. Jeanmart, S. Lantuejoul, F. Arbib, M.H. Laverriere, E. Brambilla, and C. Brambilla Clinical prognostic indicators of high-grade pre-invasive bronchial lesions Eur. Respir. J., July 1, 2004; 24(1): 24 - 29. [Abstract] [Full Text] [PDF]

				D. Moro-Sibilot, M. Jeanmart, S. Lantuejoul, F. Arbib, M. H. Laverriere, E. Brambilla, and C. Brambilla Cigarette Smoking, Preinvasive Bronchial Lesions, and Autofluorescence Bronchoscopy Chest, December 1, 2002; 122(6): 1902 - 1908. [Abstract] [Full Text] [PDF]

				E. Brambilla, S. Gazzeri, D. Moro, S. Lantuejoul, S. Veyrenc, and C. Brambilla Alterations of Rb Pathway (Rb-p16INK4-Cyclin D1) in Preinvasive Bronchial Lesions Clin. Cancer Res., February 1, 1999; 5(2): 243 - 250. [Abstract] [Full Text] [PDF]