ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Egan, T. M.
Right arrow Articles by Wilcox, B. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Egan, T. M.
Right arrow Articles by Wilcox, B. R.

The Annals of Thoracic Surgery, Vol 55, 1453-1459, Copyright © 1993 by The Society of Thoracic Surgeons

ARTICLES

Effect of a free radical scavenger on cadaver lung transplantation

TM Egan, KS Ulicny Jr, CJ Lambert Jr and BR Wilcox
Department of Surgery, University of North Carolina School of Medicine, Chapel Hill.

The pulmonary donor pool would increase substantially if lungs could be safely transplanted after cessation of circulation. To determine whether the addition of the free radical scavenger dimethylthiourea to the perfusate of cadaver lungs could improve graft function, canine donors were sacrificed, and lungs retrieved 2 hours after death. In a blinded fashion, dimethylthiourea was added to the modified Euro- Collins solution and infused into recipients (n = 9) perioperatively; a placebo was included in the perfusate of control animals (n = 9). Donor animals were ventilated with 100% oxygen only during flush and harvest. Recipients were rendered dependent upon the single left transplanted lung by occlusion of the right pulmonary artery and bronchus 1 hour after transplantation. Ventilation was maintained at a constant inspiratory oxygen fraction of 0.4. Recipients were followed up for 8 hours or until death. Three of 9 control animals survived the 8-hour observation period, whereas 6 of 9 recipients of cadaver lungs harvested with dimethylthiourea survived the observation period. Two deaths in the dimethylthiourea group occurred after 7 hours, implying that the effects of the ischemia and reperfusion injury were ameliorated by the use of this agent in this model. This study supports the notion that perfusate modification may improve the yield of cadaver lung retrieval and may allow for transplantation of lungs harvested from cadavers after cessation of circulation.


This article has been cited by other articles:


Home page
 Ann. Thorac. Surg.Home page
C. E. Reed
General thoracic surgery and the Southern Thoracic Surgical Association: the second 25 years
Ann. Thorac. Surg., November 1, 2003; 76(90050): S14 - 16.
[Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
H. Kishima, S.-i. Takeda, S. Miyoshi, A. Matsumura, M. Minami, T. Utsumi, K.-i. Omori, K. Nakahara, and H. Matsuda
Microvascular Permeability of the Non-Heart-Beating Rabbit Lung After Warm Ischemia and Reperfusion: Role of Neutrophil Elastase
Ann. Thorac. Surg., April 1, 1998; 65(4): 913 - 918.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
D. R. Jones, R. M. Becker, S. C. Hoffmann, J. J. Lemasters, and T. M. Egan
When does the lung die? Kfc, cell viability, and adenine nucleotide changes in the circulation-arrested rat lung
J Appl Physiol, July 1, 1997; 83(1): 247 - 252.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
S. Murakami, E. A. Bacha, P. Herve, H. Detruit, A. R. Chapelier, P. G. Dartevelle, and G.-M. Mazmanian
Prevention of Reperfusion Injury by Inhaled Nitric Oxide in Lungs Harvested From Non-Heart-Beating Donors
Ann. Thorac. Surg., December 1, 1996; 62(6): 1632 - 1638.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
A. M. D'Armini, J. J. Lemasters, and T. M. Egan
Studies of Rat Lung Viability and Adenine Nucleotide Metabolism After Death
Ann. Thorac. Surg., November 1, 1996; 62(5): 1448 - 1453.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
M. Yamashita, R. A. Schmid, S. Fujino, J. D. Cooper, and G. A. Patterson
NICORANDIL, A POTENT ADENOSINE TRIPHOSPHATE-SENSITIVE POTASSIUM-CHANNEL OPENER, AMELIORATES LUNG ALLOGRAFT REPERFUSION INJURY
J. Thorac. Cardiovasc. Surg., November 1, 1996; 112(5): 1307 - 1314.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
M. Yamashita, R. A. Schmid, K. Ando, J. D. Cooper, and G. A. Patterson
Nitroprusside Ameliorates Lung Allograft Reperfusion Injury
Ann. Thorac. Surg., September 1, 1996; 62(3): 791 - 796.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
C. S. Roberts, A. M. D'Armini, and T. M. Egan
CANINE DOUBLE-LUNG TRANSPLANTATION WITH CADAVERIC DONORS
J. Thorac. Cardiovasc. Surg., September 1, 1996; 112(3): 577 - 583.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
M. C. Mauney, J. T. Cope, O. A. R. Binns, R. C. King, K. S. Shockey, S. A. Buchanan, S. W. Wilson, J. Cogbill, I. L. Kron, and C. G. Tribble
Non-Heart-Beating Donors: A Model of Thoracic Allograft Injury
Ann. Thorac. Surg., July 1, 1996; 62(1): 54 - 61.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
R. J. Novick, K. E. Gehman, I. S. Ali, and J. Lee
Lung Preservation: The Importance of Endothelial and Alveolar Type II Cell Integrity
Ann. Thorac. Surg., July 1, 1996; 62(1): 302 - 314.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
M. Yamashita, R. A. Schmid, K. Okabayashi, K. Ando, J. Kobayashi, J. D. Cooper, and G. A. Patterson
Pentoxifylline in Flush Solution Improves Early Lung Allograft Function
Ann. Thorac. Surg., April 1, 1996; 61(4): 1055 - 1061.
[Abstract] [Full Text]

Home page
 J. Thorac. Cardiovasc. Surg.Home page
G. Wu, F. Zhang, R. K. Salley, J. N. Diana, T.-P. Su, and S. Chien
DELTA OPIOID EXTENDS HYPOTHERMIC PRESERVATION TIME OF THE LUNG
J. Thorac. Cardiovasc. Surg., January 1, 1996; 111(1): 259 - 267.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
L. Normandin, P. Herve, C. Brink, A. R. Chapelier, P. G. Dartevelle, and G.-M. Mazmanian
L-Arginine and Pentoxifylline Attenuate Endothelial Dysfunction After Lung Reperfusion Injury in the Rabbit
Ann. Thorac. Surg., September 1, 1995; 60(3): 646 - 650.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
S. A. Buchanan, N. F. DeLima, O. A. R. Binns, M. C. Mauney, J. T. Cope, S. E. Langenburg, K. S. Shockey, J. D. Bianchi, V. I. Parekh, C. G. Tribble, et al.
Pulmonary Function After Non-Heart-Beating Lung Donation in a Survival Model
Ann. Thorac. Surg., July 1, 1995; 60(1): 38 - 44.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
Y. Umemori, H. Date, K. Uno, M. Aoe, A. Ando, and N. Shimizu
Improved Lung Function by Urokinase Infusion in Canine Lung Transplantation Using Non-Heart-Beating Donors
Ann. Thorac. Surg., June 1, 1995; 59(6): 1513 - 1518.
[Abstract] [Full Text]

Home page
 Ann. Thorac. Surg.Home page
K. Uthoff, K. J. Zehr, P. C. Lee, R. A. Low, W. A. Baumgartner, D. E. Cameron, and R. S. Stuart
Neutrophil Modulation Results in Improved Pulmonary Function After 12 and 24 Hours of Preservation
Ann. Thorac. Surg., January 1, 1995; 59(1): 7 - 13.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1993 by The Society of Thoracic Surgeons.