HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Martin, S. M. Articles by Bhuta, S. Search for Related Content PubMed PubMed Citation Articles by Martin, S. M. Articles by Bhuta, S.

The Annals of Thoracic Surgery, Vol 55, 954-960, Copyright © 1993 by The Society of Thoracic Surgeons

ARTICLES

Perfluorochemical reperfusion yields improved myocardial recovery after global ischemia

SM Martin, H Laks, DC Drinkwater, DG Stein, ER Capouya, JM Pearl, SW Barthel, P Chang, E Kaczer and S Bhuta
Division of Cardiothoracic Surgery, University of California, Los Angeles Medical Center 90024.

Reperfusion injury remains a limiting factor in extending ischemic storage time for human heart transplantation. In this study, initial myocardial reperfusion with an oxygenated perfluorochemical (Fluosol) was investigated as a means of limiting such injury. Neonatal piglet hearts were arrested with crystalloid cardioplegia, excised, and stored for 12 hours in saline solution at 0 degrees C. Initial reperfusion (10 minutes) was either with whole blood (n = 6), unmodified perfluorochemical (n = 8), or aspartate/glutamate-enriched perfluorochemical cardioplegia (n = 6), and was followed by an additional 40 minutes of whole blood perfusion. Functional evaluation was then completed, and left ventricular biopsy specimens were taken. A control group (n = 7) was evaluated without an intervening period of ischemia. At a left ventricular end-diastolic pressure of 9 mm Hg, hearts stored in whole blood cardioplegia developed a left-ventricular stroke work index of 3.8 +/- 2.3 x 10(3) erg/g (mean +/- standard error of the mean). Under the same conditions, perfluorochemical-reperfused hearts achieved a stroke work index of 14.6 +/- 1.3 x 10(3) erg/g, significantly greater than that of the whole blood group (p < 0.001). Stroke work index for hearts reperfused with aspartate/glutamate- enriched perfluorochemical cardioplegia was 19.8 +/- 1.6 x 10(3) erg/g, significantly increased over that of the nonenriched perfluorochemical group (p < 0.01) and not different from values obtained in controls (19.2 +/- 0.8 x 10(3) erg/g).(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				J. A. Wahr and K. K. Tremper Blood Substitutes in Cardiac Surgery Seminars in Cardiothoracic and Vascular Anesthesia, November 1, 1998; 2(4): 272 - 282. [Abstract] [PDF]

				A. Marchbank Fluorocarbon emulsions Perfusion, March 1, 1995; 10(2): 67 - 88. [PDF]