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The Annals of Thoracic Surgery, Vol 55, 917-922, Copyright © 1993 by The Society of Thoracic Surgeons
YJ Gu, W van Oeveren, C Akkerman, PW Boonstra, RJ Huyzen and CR Wildevuur
Cardiopulmonary bypass generates a systemic inflammatory response including
the activation of the complement cascade and leukocytes contributing to
postoperative morbidity. To evaluate whether the use of heparin-coated
extracorporeal circuits could reduce these activation processes, we
performed a study on 30 patients undergoing coronary artery bypass grafting
who were randomly perfused with a heparin-coated circuit (Duraflo II, n =
15) or with a similar noncoated circuit (control, n = 15). Standardized
systemic heparinization was applied for every patient before
cardiopulmonary bypass. The use of heparin-coated circuits resulted in a
reduction of systemic leukocyte activation during cardiopulmonary bypass
reflected by reduced elastase release (p < 0.05) and tumor necrosis
factor generation (p < 0.05) manifest after release of the aortic
cross-clamp. In addition, blood samples taken from both the right and left
atria after reperfusion revealed that the elastase release from the
pulmonary microcirculation was absent in the Duraflo II group in contrast
to the control group (p < 0.05). The pattern of complement activation,
likely initiating this inflammatory reaction, was modified by heparin
coating in two different aspects. There was a significant reduction of C3a
generation after protamine administration in patients perfused with
heparin-coated circuits, and there was a decrease of complement hemolytic
capacity in pooled human serum incubated with heparin-coated tubing. These
observations suggest that heparin coating might bind some of the complement
components from the classic pathway, thereby reducing the inflammatory
response to cardiopulmonary bypass.
ARTICLES
Heparin-coated circuits reduce the inflammatory response to cardiopulmonary bypass
Thorax Centre, University Hospital, Groningen, The Netherlands.
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|
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|
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P. M. McCarthy, J.-P. P. Yared, R. C. Foster, D. A. Ogella, J. A. Borsh, and D. M. Cosgrove III A prospective randomized trial of Duraflo II heparin-coated circuits in cardiac reoperations Ann. Thorac. Surg., May 1, 1999; 67(5): 1268 - 1273. [Abstract] [Full Text] [PDF]
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H. Watanabe, J.-i. Hayashi, H. Ohzeki, H. Moro, M. Sugawara, and S. Eguchi Biocompatibility of a silicone-coated polypropylene hollow fiber oxygenator in an in vitro model Ann. Thorac. Surg., May 1, 1999; 67(5): 1315 - 1319. [Abstract] [Full Text] [PDF]
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Y. J. Gu, P. W. Boonstra, and W. van Oeveren Effect of normoxic cardiopulmonary bypass on leukocyte elastase release J. Thorac. Cardiovasc. Surg., May 1, 1999; 117(5): 1045 - 1046. [Full Text]
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G. S. Aldea Heparin-Bonded Circuits Decrease Thromboembolic Complications and Improve Outcomes in Patients Undergoing Coronary Artery Bypass Graft Surgery Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 1999; 3(1): 9 - 16. [Abstract] [PDF]
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L. M. Jacquet, P. H. Noirhomme, M. J. Van Dyck, G. A. El Khoury, A. J. Matta, M. J. Goenen, and R. A. Dion Randomized trial of intermittent antegrade warm blood versus cold crystalloid cardioplegia Ann. Thorac. Surg., February 1, 1999; 67(2): 471 - 477. [Abstract] [Full Text] [PDF]
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C. Baufreton, M. Moczar, L. Intrator, P. G. Jansen, H. te Velthuis, P. Le Besnerais, J. P. Farcet, C. R. Wildevuur, and D. Y Loisance Inflammatory response to cardiopulmonary bypass using two different types of heparin-coated extracorporeal circuits Perfusion, December 1, 1998; 13(6): 419 - 427. [Abstract] [PDF]
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J. P. Gott, W. A. Cooper, F. E. Schmidt Jr, W. M. Brown III, C. E. Wright, J. D. Merlino, J. D. Fortenberry, W. S. Clark, and R. A. Guyton Modifying risk for extracorporeal circulation: trial of four antiinflammatory strategies Ann. Thorac. Surg., September 1, 1998; 66(3): 747 - 754. [Abstract] [Full Text] [PDF]
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L. A. Brasil, W. J. Gomes, R. Salomao, and E. Buffolo Inflammatory response after myocardial revascularization with or without cardiopulmonary bypass Ann. Thorac. Surg., July 1, 1998; 66(1): 56 - 59. [Abstract] [Full Text] [PDF]
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H. H. Schreurs, M. J. Wijers, Y. J. Gu, W. van Oeveren, R. T. van Domburg, J. H. de Boer, and A. J.J.C. Bogers Heparin-coated bypass circuits: effects on inflammatory response in pediatric cardiac operations Ann. Thorac. Surg., July 1, 1998; 66(1): 166 - 171. [Abstract] [Full Text] [PDF]
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C B. Mahoney Heparin-bonded circuits: clinical outcomes and costs Perfusion, May 1, 1998; 13(3): 192 - 204. [Abstract] [PDF]
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Y. J. Gu, P. W. Boonstra, A. A. Rijnsburger, J. Haan, and W. van Oeveren Cardiopulmonary Bypass Circuit Treated With Surface-Modifying Additives: A Clinical Evaluation of Blood Compatibility Ann. Thorac. Surg., May 1, 1998; 65(5): 1342 - 1347. [Abstract] [Full Text] [PDF]
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Y. J. Gu, M. A. Mariani, W. van Oeveren, J. G. Grandjean, and P. W. Boonstra Reduction of the Inflammatory Response in Patients Undergoing Minimally Invasive Coronary Artery Bypass Grafting Ann. Thorac. Surg., February 1, 1998; 65(2): 420 - 424. [Abstract] [Full Text] [PDF]
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G. S. Aldea, P. O'Gara, O. M. Shapira, P. Treanor, A. Osman, E. Patalis, C. Arkin, R. Diamond, V. Babikian, H. L. Lazar, et al. Effect of Anticoagulation Protocol on Outcome in Patients Undergoing CABG With Heparin-Bonded Cardiopulmonary Bypass Circuits Ann. Thorac. Surg., February 1, 1998; 65(2): 425 - 433. [Abstract] [Full Text] [PDF]
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A. Belboul and N. Al-Khaja Does heparin coating improve biocompatibility? A study on complement, blood cells and postoperative morbidity during cardiac surgery Perfusion, December 1, 1997; 12(6): 385 - 391. [Abstract] [PDF]
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S. Ashraf, Y. Tian, D. Cowan, A. Entress, P. G. Martin, and K. G. Watterson Release of Proinflammatory Cytokines During Pediatric Cardiopulmonary Bypass: Heparin-Bonded Versus Nonbonded Oxygenators Ann. Thorac. Surg., December 1, 1997; 64(6): 1790 - 1794. [Abstract] [Full Text]
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E. Ovrum, G. Tangen, and E. A. Holen Facing the Era of Minimally Invasive Coronary Grafting: Current Results of Conventional Bypass Grafting for Single-Vessel Disease Ann. Thorac. Surg., July 1, 1997; 64(1): 159 - 162. [Abstract] [Full Text]
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H E Hogevold, O Moen, E Fosse, P Venge, J Braten, C Andersson, and T Lyberg Effects of heparin coating on the expression of CD11b, CD11c and CD62L by leucocytes in extracorporeal circulation in vitro Perfusion, January 1, 1997; 12(1): 9 - 20. [Abstract] [PDF]
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C. Baufreton, P. G. M. Jansen, P. Le Besnerais, H. Velthuis, C. M. Thijs, C. R. H. Wildevuur, and D. Y. Loisance Heparin Coating With Aprotinin Reduces Blood Activation During Coronary Artery Operations Ann. Thorac. Surg., January 1, 1997; 63(1): 50 - 56. [Abstract] [Full Text]
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S. Ashraf, Y. Tian, D. Cowan, U. Nair, R. Chatrath, N. R. Saunders, K. G. Watterson, and P. G. Martin ""Low-Dose"" Aprotinin Modifies Hemostasis but Not Proinflammatory Cytokine Release Ann. Thorac. Surg., January 1, 1997; 63(1): 68 - 73. [Abstract] [Full Text]
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