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The Annals of Thoracic Surgery, Vol 55, 78-85, Copyright © 1993 by The Society of Thoracic Surgeons
H Lu, R Fietsam Jr, RL Hammond, H Nakajima, FW Mocek, GA Thomas, R Ruggiero, H Nakajima, M Colson and LW Stephenson
Skeletal muscle ventricles (SMVs) were constructed from the latissimus
dorsi muscle in 6 dogs. After 3 weeks of vascular delay followed by 6 weeks
of 2-Hz continuous electrical conditioning, a valved conduit was placed
between the left ventricular apex and the SMV and a second valved conduit,
between the SMV and the aorta. The SMV was stimulated to contract during
diastole at a 1:2 ratio with the heart. The SMV pumped 47% of the systemic
blood flow initially (0.73 +/- 0.23 versus 1.54 +/- 0.42 L/min) and 40%
after 3 hours. Skeletal muscle ventricle stimulation resulted in a 58%
increase in mean diastolic pressure initially (52 +/- 9 to 82 +/- 11 mm Hg;
p < 0.05) and a 73% increase (45 +/- 7 to 78 +/- 8 mm Hg) after 3 hours
of continuous pumping. This was associated with a 68% increase in the
endocardial viability ratio initially and a 63% increase at 3 hours. The
systolic tension-time index decreased by 26% initially and 25% at 3 hours.
This study indicates that the SMV configuration of left ventricular apex to
aorta may be particularly suitable for left ventricular assist.
ARTICLES
Skeletal muscle ventricles: left ventricular apex to aorta configuration
Department of Surgery, Wayne State University, Detroit, Michigan 48225.
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J. C. Jarvis, M. M.N. Kwende, A. Shortland, R. M. Eloakley, S. J. Gilroy, R. A. Black, and S. Salmons Relation Between Muscle Contraction Speed and Hydraulic Performance in Skeletal Muscle Ventricles Circulation, October 7, 1997; 96(7): 2368 - 2375. [Abstract] [Full Text]
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