ATS
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Personal Folders
Right arrow Download to citation manager
Right arrow Permission Requests
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Takeuchi, K.
Right arrow Articles by Koyama, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Takeuchi, K.
Right arrow Articles by Koyama, K.

The Annals of Thoracic Surgery, Vol 54, 327-332, Copyright © 1992 by The Society of Thoracic Surgeons

ARTICLES

A prostacyclin analogue reduces free radical generation in heart-lung transplantation

K Takeuchi, S Suzuki, N Kako, M Kobayashi, S Takahashi, M Sawada, T Honma, S Iwabuchi, K Fukui and K Koyama
Hirosaki University School of Medicine, Japan.

The mechanism by which prostacyclin acts to prevent in vivo reperfusion injury is still uncertain. This study was therefore undertaken to assess the effect of a stable prostacyclin analogue (OP 41483-alpha-CD [OP]) on oxygen-derived free radicals after heart-lung transplantation. OP was administered to the heart-lung graft through the pulmonary artery for 25 minutes encompassing the reperfusion process. Free radicals were directly measured by electron spin resonance spectroscopy. The radical intensities of pulmonary venous blood were significantly lower in the OP group than in the control group, suggesting that fewer free radicals were generated in the lungs of the OP group. The cardiac and respiratory function were better in the OP group than in the control group. The lung is the primary source of oxygen free radical attack, and the beneficial action of OP on free radical generation is almost exclusively restricted to the lung and does not apply to the heart. This result suggested that OP probably is effective in inhibiting free radical generation from the endothelium.


This article has been cited by other articles:


Home page
 J. Thorac. Cardiovasc. Surg.Home page
D. Johnson, D. Thomson, T. Hurst, K. Prasad, T. Wilson, F. Murphy, A. Saxena, and I. Mayers
Neutrophil-mediated acute lung injury after extracorporeal perfusion
J. Thorac. Cardiovasc. Surg., May 1, 1994; 107(5): 1193 - 1202.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
ANN THORAC SURG ASIAN CARDIOVASC THORAC ANN EUR J CARDIOTHORAC SURG
J THORAC CARDIOVASC SURG ICVTS ALL CTSNet JOURNALS
Copyright © 1992 by The Society of Thoracic Surgeons.