HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Carp, N. Z. Articles by Keller, S. M. Search for Related Content PubMed PubMed Citation Articles by Carp, N. Z. Articles by Keller, S. M.

The Annals of Thoracic Surgery, Vol 53, 680-683, Copyright © 1992 by The Society of Thoracic Surgeons

ARTICLES

DNA content in correlation with postsurgical stage in non-small cell lung cancer

NZ Carp, DD Ellison, PF Brophy, P Watts, MC Chang and SM Keller
Department of Surgical Oncology, Fox Chase Cancer Center, Philadelphia, PA 19111.

The relationship between DNA content, TNM stage, tumor size, grade, histology, and disease-free survival was assessed in a retrospective study of patients with non-small cell lung cancer who had undergone resection and complete mediastinal lymph node dissection. Flow cytometric analysis was performed on paraffin-embedded tissue of 90 consecutive patients. The patients were analyzed both as a group and by individual stage. Median follow-up was 11 months (range, 1 to 35 months). Aneuploid tumors were not significantly different from diploid tumors with regard to pathologic TNM stage (p = 0.34), size (p = 0.5), grade (p = 0.5), or histology (p = 0.34). Disease-free survival of patients with aneuploid tumors was not significantly different than that of patients whose tumors had normal DNA content (p = 0.69). DNA content did not correlate with established prognostic factors in patients with non-small cell lung cancer who underwent resection and complete mediastinal lymph node dissection.

This article has been cited by other articles:

				M. D. Brundage, D. Davies, and W. J. Mackillop Prognostic Factors in Non-small Cell Lung Cancer* : A Decade of Progress Chest, September 1, 2002; 122(3): 1037 - 1057. [Abstract] [Full Text] [PDF]

				W. Dyszkiewicz, M. Kasprzyk, C. Piwkowski, and L. Gasiorowski Prognostic significance of DNA ploidy in squamous cell lung carcinoma: is it really worth it? Ann. Thorac. Surg., November 1, 2000; 70(5): 1629 - 1633. [Abstract] [Full Text] [PDF]