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The Annals of Thoracic Surgery, Vol 53, 240-245, Copyright © 1992 by The Society of Thoracic Surgeons
R Aeba, RJ Keenan, RL Hardesty, SA Yousem, I Hamamoto and BP Griffith
University of Wisconsin and modified Euro-Collins solutions for pulmonary
preservation were compared in a rat orthotopic left lung isotransplant
model. Heart-lung blocks of donor rats were flushed with and preserved in
one of the preservation solutions at 0 degrees C. After 6 or 12 hours of
cold ischemia, the left lungs were transplanted into recipient rats and
reperfused for 1 hour. Pulmonary function was assessed by measuring oxygen
and carbon dioxide tensions in arterial blood after removal of the right
lung. Lipid peroxide concentrations were measured as thiobarbiturate
acid-reactive substances. The ratios of wet to dry weight of grafts after
ischemia and after reperfusion were calculated. Histologic changes of
ischemia-reperfusion injury of the lung tissue were evaluated using a
graded scale. Oxygen tension after 6 hours of preservation followed by
reperfusion was significantly higher with University of Wisconsin solution
(308.8 +/- 81.1 mm Hg) than with Euro-Collins solution (50.8 +/- 17.8 mm
Hg; p less than 0.001). Carbon dioxide tension in the University of
Wisconsin solution group was also significantly lower than in the
Euro-Collins solution group (28.2 +/- 2.3 versus 46.0 +/- 4.5 mm Hg; p less
than 0.05). Lipid peroxide concentration after 6 hours' preservation in
University of Wisconsin solution was significantly lower (0.88 +/- 0.07
mumol/g) than that in Euro-Collins solution (1.26 +/- 0.12 mumol/g; p less
than 0.05). After 12 hours of preservation only lipid peroxide
concentration with University of Wisconsin solution was significantly lower
(1.30 +/- 0.09 mumol/g) than with Euro-Collins solution (1.71 +/- 0.15
mumol/g; p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
ARTICLES
University of Wisconsin solution for pulmonary preservation in a rat transplant model
Department of Surgery, University of Pittsburgh, Pennsylvania 15261.
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