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The Annals of Thoracic Surgery, Vol 52, 541-543, Copyright © 1991 by The Society of Thoracic Surgeons

ARTICLES

Complement activation during bypass in acquired C1 esterase inhibitor deficiency

RS Bonser, J Dave, J Morgan, C Morgan, E Davies, P Taylor, H Gaya, L John, M Paneth and D Vergani
Brompton Hospital, London, United Kingdom.

Serial complement estimations during cardiopulmonary bypass are reported in a patient with acquired C1 esterase inhibitor deficiency. Although the extent of classic and alternative pathway activation appeared appropriate, exaggerated common pathway activation with massive increase in the C3d:C3 ratio occurred. A fatal hemostatic disorder, pulmonary edema, and circulatory collapse ensued despite prophylaxis and therapy.


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