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The Annals of Thoracic Surgery, Vol 52, 523-528, Copyright © 1991 by The Society of Thoracic Surgeons
PO Kimblad, T Sjoberg, G Massa, JO Solem and S Steen
Euro-Collins (ECS) and UCLA-formula organ preservation solutions induced
strong vasocontraction in porcine pulmonary arteries when studied in organ
baths at temperatures of 37 degrees C and 30 degrees C. At 20 degrees C ECS
induced a 30% contraction, but at 6 degrees C no contraction (n = 5) or a
weak contraction (n = 1) was elicited. Neither prostaglandin E1 nor
nifedipine caused any significant reduction of the vasocontraction elicited
by ECS and UCLA. Krebs solution, enriched with potassium in amounts
corresponding to those in ECS (115 mmol/L) or UCLA (30 mmol/L), induced
vasocontraction comparing well with those induced by ECS or UCLA,
indicating that it is the high potassium content that causes the
vasocontraction. In a second experiment lung segments were stored at 4
degrees C for 9 hours in ECS, UCLA, or Krebs solution. Pulmonary arterial
segments were then studied in organ baths at 37 degrees C. The choice of
preservation solution did not significantly affect the contractile
properties of potassium, noradrenaline, or the thromboxane mimic U-46619.
To conclude, high potassium contents in organ preservation solutions induce
strong pulmonary vasocontraction in lung temperatures greater than 20
degrees C but not in temperatures less than 10 degrees C. These
vasocontractions are not significantly reduced by prostaglandin E1 or
nifedipine. We suggest that the initial preservation solution used to cool
down the lungs should contain 4 mmol/L or no potassium. When the lung
temperature is less than 10 degrees C, a second perfusion might be done,
and then a high potassium content (if thought to be essential) will not
cause vasocontraction.
ARTICLES
High potassium contents in organ preservation solutions cause strong pulmonary vasocontraction
Department of Cardiothoracic Surgery, University Hospital, Lund, Sweden.
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