HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Zenati, M. Articles by Griffith, B. P. Search for Related Content PubMed PubMed Citation Articles by Zenati, M. Articles by Griffith, B. P.

The Annals of Thoracic Surgery, Vol 48, 882-886, Copyright © 1989 by The Society of Thoracic Surgeons

ARTICLES

Organ procurement for pulmonary transplantation

M Zenati, RD Dowling, JM Armitage, RL Kormos, JS Dummer, RL Hardesty and BP Griffith
Department of Surgery, University of Pittsburgh, Pennsylvania.

Selection of suitable donors is critical to the success of clinical pulmonary transplantation. Requirements for lung donors, management before explantation, and methods of preservation were reviewed for the 70 heart-lung, eight double-lung, and two single-lung transplantations performed at the University of Pittsburgh since 1982. Careful observation of trends of hyperoxygenation studies, chest roentgenograms, and Gram stain and culture results of tracheal secretions, as well as findings on bronchoscopy, can help identify which lungs not only have adequate function but are acceptable for transplantation. In spite of the rigid criteria used, 76% of tracheal cultures from donors deemed acceptable grew organisms. The presence of oropharyngeal flora has been shown to correlate with the development of early intrathoracic infections in the recipient. Prophylactic broad- spectrum antibiotic treatment of the donor is desirable to treat microbial contamination that could cause focal injury to the donor lung and predispose to infection in the recipient. Acceptance of less than ideal donors is ill-advised even though rejection of such donors conflicts with the current shortage of organs.

This article has been cited by other articles:

				D. Van Raemdonck, A. Neyrinck, G. M. Verleden, L. Dupont, W. Coosemans, H. Decaluwe, G. Decker, P. De Leyn, P. Nafteux, and T. Lerut Lung Donor Selection and Management Proceedings of the ATS, January 15, 2009; 6(1): 28 - 38. [Abstract] [Full Text] [PDF]

				V. S. Avlonitis, A. Krause, L. Luzzi, H. Powell, J. A. Phillips, P. A. Corris, F. K. Gould, and J. H. Dark Bacterial colonization of the donor lower airways is a predictor of poor outcome in lung transplantation Eur. J. Cardiothorac. Surg., October 1, 2003; 24(4): 601 - 607. [Abstract] [Full Text] [PDF]

				J. S. Gammie, D. R. Stukus, S. M. Pham, B. G. Hattler, M. F. McGrath, K. R. McCurry, B. P. Griffith, and R. J. Keenan Effect of ischemic time on survival in clinical lung transplantation Ann. Thorac. Surg., December 1, 1999; 68(6): 2015 - 2019. [Abstract] [Full Text] [PDF]

				J. S. Gammie, J. C. Lee, S. M. Pham, R. J. Keenan, R. J. Weyant, B. G. Hattler, and B. P. Griffith Cardiopulmonary bypass is associated with early allograft dysfunction but not death after double-lung transplantation J. Thorac. Cardiovasc. Surg., May 1, 1998; 115(5): 990 - 994. [Abstract] [Full Text] [PDF]

				J. S. Gammie, R. J. Keenan, S. M. Pham, M. F. McGrath, B. G. Hattler, E. Khoshbin, and B. P. Griffith Single- Versus Double-Lung Transplantation For Pulmonary Hypertension J. Thorac. Cardiovasc. Surg., February 1, 1998; 115(2): 397 - 403. [Abstract] [Full Text]

				R. J. Novick Invited Commentary Ann. Thorac. Surg., October 1, 1995; 60(4): 962 - 963. [Full Text]