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The Annals of Thoracic Surgery, Vol 48, 218-221, Copyright © 1989 by The Society of Thoracic Surgeons

ARTICLES

Neoadjuvant therapy of squamous cell carcinoma of the esophagus: role of resection and benefit in partial responders

VL Lackey, MT Reagan, RA Smith and WJ Anderson
Department of Surgery, Mississippi Baptist Medical Center, Jackson.

Twenty-eight patients were treated between 1981 and 1987 with a combination of radiation therapy and two courses of 5-fluorouracil and cisplatin followed by esophageal resection. Sixteen patients (57%) underwent resection. Operative mortality was 6% (1 of 16), and the 15 operative survivors have been followed for more than 23 months. Complete pathological response was achieved in 8 of the 15 patients, and 10 patients (66%) are alive with no evidence of disease; 4 patients (27%) have survived with no evidence of disease for more than 5 years. Four partial responders are alive, and 3 are alive with no evidence of disease for more than 5 years. An aggressive approach with a low mortality has demonstrated survival benefit to complete responders and, contrary to findings of previous reports, has established a role for surgical resection and survival benefit in patients with partial response, with 3 of 7 (47%) patients surviving more than 5 years.


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 Eur. J. Cardiothorac. Surg.Home page
A. Imdahl, G. Bognar, J. Schulte-Monting, U. Schoffel, E.H. Farthmann, and C. Ihling
Predictive factors for response to neoadjuvant therapy in patients with oesophageal cancer
Eur. J. Cardiothorac. Surg., April 1, 2002; 21(4): 657 - 663.
[Abstract] [Full Text] [PDF]


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