HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Menasche, P. Articles by Piwnica, A. Search for Related Content PubMed PubMed Citation Articles by Menasche, P. Articles by Piwnica, A.

The Annals of Thoracic Surgery, Vol 47, 939-945, Copyright © 1989 by The Society of Thoracic Surgeons

ARTICLES

Free radicals and myocardial protection: a surgical viewpoint

P Menasche and A Piwnica
Department of Cardiovascular Surgery, Hopital Lariboisiere, Paris, France.

Oxygen-derived free radicals are now considered important contributors to tissue injury associated with ischemia and reperfusion. Transition metals, primarily iron, greatly enhance the generation of these active species, which can destroy a large variety of biomolecules, in particular the lipid components of cell membranes. This review tries to demonstrate why cardiopulmonary bypass and aortic cross-clamping are situations that predispose to oxygen free radical production, and how "anti-free radical" agents such as enzymatic scavengers, antioxidants, and iron chelators may prove to be useful therapeutic adjuncts in the clinical setting of open heart surgery.

This article has been cited by other articles:

				P. Biglioli, A. Cannata, F. Alamanni, M. Naliato, M. Porqueddu, M. Zanobini, E. Tremoli, and A. Parolari Biological effects of off-pump vs. on-pump coronary artery surgery: focus on inflammation, hemostasis and oxidative stress Eur. J. Cardiothorac. Surg., August 1, 2003; 24(2): 260 - 269. [Abstract] [Full Text] [PDF]

				P. Menasche and L. H. Edmunds Jr. Extracorporeal Circulation: The Inflammatory Response Card. Surg. Adult, January 1, 2003; 2(2003): 349 - 360. [Full Text]

				A. Parolari, P. Rubini, A. Cannata, L. Bonati, F. Alamanni, E. Tremoli, and P. Biglioli Endothelial damage during myocardial preservation and storage Ann. Thorac. Surg., February 1, 2002; 73(2): 682 - 690. [Abstract] [Full Text] [PDF]

				N. Hayashida, T. Isomura, T. Sato, H. Maruyama, T. Higashi, K. Arinaga, and S. Aoyagi Minimally Diluted Tepid Blood Cardioplegia Ann. Thorac. Surg., March 1, 1998; 65(3): 615 - 621. [Abstract] [Full Text] [PDF]

				D P JENKINS Are patients with poor left ventricular function more prone to oxidative stress during cardiac surgery? Heart, March 1, 1998; 79(3): 219 - 219. [Full Text]

				M. A. Wait and P. A. Grayburn Effect of preoperative antioxidant supplements on perioperative myocardial injury J. Thorac. Cardiovasc. Surg., December 1, 1997; 114(6): 1127 - 1128. [Full Text]

				J. Westhuyzen, A. D. Cochrane, P. J. Tesar, T. Mau, D. B. Cross, M. P. Frenneaux, F. A. Khafagi, and S. J. Fleming EFFECT OF PREOPERATIVE SUPPLEMENTATION WITH {{alpha}}-TOCOPHEROL AND ASCORBIC ACID ON MYOCARDIAL INJURY IN PATIENTS UNDERGOING CARDIAC OPERATIONS J. Thorac. Cardiovasc. Surg., May 1, 1997; 113(5): 942 - 948. [Abstract] [Full Text]

				D. Royston Systemic inflammatory responses to surgery with cardiopulmonary bypass Perfusion, May 1, 1996; 11(3): 177 - 189. [PDF]

				E. J. Pesonen, R. Korpela, K. Peltola, M. Leijala, H. Sairanen, K. O. Raivio, P. Venge, and S. Andersson Regional generation of free oxygen radicals during cardiopulmonary bypass in children J. Thorac. Cardiovasc. Surg., September 1, 1995; 110(3): 768 - 773. [Abstract] [Full Text]

				A. Mezzetti, A. M. Calafiore, D. Lapenna, R. Deslauriers, G. Tian, T. A. Salerno, A. M. Verna, G. Bosco, S. D. Pierdomenico, and F. Caccurullo Intermittent antegrade warm cardioplegia reduces oxidative stress and improves metabolism of the ischemic-reperfused human myocardium J. Thorac. Cardiovasc. Surg., April 1, 1995; 109(4): 787 - 795. [Abstract] [Full Text]

				Shu Tao, G. Calza, F. Lerzo, A. Virgone, N. Camassa, G. Panizzon, L. Brunelli, R. Moretti, P. Grasso, G. Ghiggeri, et al. Activation of the intracellular glutathione system by oxydative stress during cardiopulmonary bypass and myocardial perfusion Perfusion, January 1, 1995; 10(1): 45 - 50. [Abstract] [PDF]

				K. Ihnken, F. Beyersdorf, Z. Mitrev, U. Unkelbach, Y. Poloczek, R. Hallmann, and G. Zimmer Controlled Reperfusion Reduces Reperfusion Injury in Skeletal Muscle After Incomplete Limb Ischemia Vascular and Endovascular Surgery, May 1, 1994; 28(4): 241 - 259. [Abstract] [PDF]

				A. K. Qayumi, M. T. Janusz, K. Dorovini-Zis, D. M. Lyster, W. R. Eric Jamieson, A. Poostizadeh, E. J. E. Feeley, and M. Nikbakht-Sangari Additive effect of allopurinol and deferoxamine in the prevention of spinal cord injury caused by aortic crossclamping J. Thorac. Cardiovasc. Surg., May 1, 1994; 107(5): 1203 - 1209. [Abstract] [Full Text]

				R. Federico Ferreira, J. Milei, S. Llesuy, B. Gonzalez Flecha, H. Hourquebie, L. Molteni, C. de Palma, A. Paganini, L. Scervino, and A. Boveris Antioxidant Action of Vitamins A and E in Patients Submitted to Coronary Artery Bypass Surgery Vascular and Endovascular Surgery, April 1, 1991; 25(3): 191 - 195. [Abstract] [PDF]