HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Masuda, H. Articles by Kikuchi, K. Search for Related Content PubMed PubMed Citation Articles by Masuda, H. Articles by Kikuchi, K.

The Annals of Thoracic Surgery, Vol 47, 890-896, Copyright © 1989 by The Society of Thoracic Surgeons

ARTICLES

Physiological changes during temporary occlusion of the superior vena cava in cynomolgus monkeys

H Masuda, T Ogata and K Kikuchi
Second Department of Surgery, National Defense Medical College, Saitama, Japan.

To evaluate the physiological changes that occur after temporary occlusion of the superior vena cava, we clamped the vena cava for one hour in 6 cynomolgus monkeys, monkeys with a venous system most resembling that of humans. The data from arterial blood gas analysis, ie, pH, arterial oxygen tension, arterial carbon dioxide tension, and HCO3-, were within normal limits during and after occlusion of the superior vena cava. Intracranial pressure was 8.6 +/- 0.8 mm Hg (mean +/- standard error) before occlusion and rose to 22.1 +/- 2.2 mm Hg during clamping. It decreased significantly to 17.7 +/- 1.9 mm Hg just before removal of the clamp and recovered to 8.6 +/- 0.9 mm Hg after the clamp was removed. Regional cerebral blood flow was 45 +/- 9 mL/min/100 g before clamping and decreased to 37 +/- 3 mL/min/100 g during clamping. It recovered to 47 +/- 5 mL/min/100 g after removal of the clamp. Cerebral perfusion pressure was within the margin of safety during clamping. Histological findings in the brain showed the effect of congestion in 1 monkey, but the change was slight. The electroencephalogram and electrocardiogram showed no abnormalities in this experiment. In conclusion, one-hour clamping of the superior vena cava with the azygos vein ligated was safe in 6 cynomolgus monkeys. We believe that in the clinical setting, one-hour occlusion of the superior vena cava would result in findings similar to those in this study, unless particular complications, such as arteriosclerosis or a cerebrovascular disorder, exist.

This article has been cited by other articles:

				K. Suzuki, H. Asamura, S.-i. Watanabe, and R. Tsuchiya Combined Resection of Superior Vena Cava for Lung Carcinoma: Prognostic Significance of Patterns of Superior Vena Cava Invasion Ann. Thorac. Surg., October 1, 2004; 78(4): 1184 - 1189. [Abstract] [Full Text] [PDF]

				L. Spaggiari, P. Thomas, P. Magdeleinat, H. Kondo, G. Rollet, J. F. Regnard, R. Tsuchiya, and U. Pastorino Superior vena cava resection with prosthetic replacement for non-small cell lung cancer: long-term results of a multicentric study Eur. J. Cardiothorac. Surg., June 1, 2002; 21(6): 1080 - 1086. [Abstract] [Full Text] [PDF]

				J. A. Gonzalez-Fajardo, M. Garcia-Yuste, S. Florez, G. Ramos, T. Alvarez, and J. M. Coca Hemodynamic and cerebral repercussions arising from surgical interruption of the superior vena cavaExperimental model J. Thorac. Cardiovasc. Surg., April 1, 1994; 107(4): 1044 - 1049. [Abstract] [Full Text]