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The Annals of Thoracic Surgery, Vol 47, 857-859, Copyright © 1989 by The Society of Thoracic Surgeons

ARTICLES

Effect of surgical blood loss and volume replacement on antibiotic pharmacokinetics

D Sue, TA Salazar, K Turley and BJ Guglielmo
Division of Clinical Pharmacy, University of California, San Francisco 94143.

Antibiotic prophylaxis is used widely to prevent postoperative infection associated with cardiac operations. The influence of perioperative blood loss on antibiotic pharmacokinetics has not been well studied. Plasma cefazolin sodium samples from 8 patients undergoing a cardiac operation were collected postoperatively and analyzed. The results suggest that blood loss has a minimal effect on the elimination of cefazolin and that therapeutic concentrations are maintained without altering the dosage regimen.


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S. M. Swoboda, C. Merz, J. Kostuik, B. Trentler, and P. A. Lipsett
Does Intraoperative Blood Loss Affect Antibiotic Serum and Tissue Concentrations?
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[Abstract] [PDF]

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M. J. J. METER, M. D. W. POLLY JR., L. C. R. P. BRUECKNER, M. J. J. TENUTA, L. ASPLUND, and W. J. HOPKINSON
Effect of Intraoperative Blood Loss on the Serum Level of Cefazolin in Patients Managed with Total Hip Arthroplasty. A Prospective, Controlled Study
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