HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bodnar, E. Articles by Ross, D. N. Search for Related Content PubMed PubMed Citation Articles by Bodnar, E. Articles by Ross, D. N.

The Annals of Thoracic Surgery, Vol 47, 799-805, Copyright © 1989 by The Society of Thoracic Surgeons

ARTICLES

Viable and nonviable aortic homografts in the subcoronary position: a comparative study

E Bodnar, O Matsuki, R Parker and DN Ross
Cardiothoracic Institute, National Heart Hospital, London, England.

One hundred fifty-five freeze-dried, 63 frozen, and 337 Hanks'- antibiotic solution preserved or nutrient-antibiotic solution preserved homografts used for isolated aortic valve replacement have been followed for 1 to 20 years (mean, 5.3 years), a total of 2,931 patient- years of follow-up information. Overall survival, valve-related death, primary tissue failure, failure due to surgical technical error, infective endocarditis, and overall event-free survival have been assessed and compared. Overall survival 20 years after operation was 51.6% +/- 8.1% with a low incidence of sudden death. The method and length of preservation did not have any effect on the long-term performance or the mode of failure of the homografts. The rate of primary tissue failure was apparently higher with valves preserved in a solution containing calf serum, but the difference was not significant. It is concluded that long-term patient survival and quality of life after aortic valve replacement with a homograft are excellent. The current study, however, could not verify the existence of a significant difference between the three assessed methods of homograft preservation. Furthermore, it could not prove the importance of cellular viability or the existence of clinically significant immunological factors other than the calf serum content of the nutrient medium.

This article has been cited by other articles:

				T. Athanasiou, C. Jones, R. Jin, G. L. Grunkemeier, and D. N. Ross Homograft Implantation Techniques in the Aortic Position: To Preserve or Replace the Aortic Root? Ann. Thorac. Surg., May 1, 2006; 81(5): 1578 - 1585. [Abstract] [Full Text] [PDF]

				J. Aagaard and P. V. Andersen Acute endocarditis treated with radical debridement and implantation of mechanical or stented bioprosthetic devices Ann. Thorac. Surg., January 1, 2001; 71(1): 100 - 103. [Abstract] [Full Text] [PDF]

				M. Homann, J. C. Haehnel, N. Mendler, S. U. Paek, K. Holper, H. Meisner, and R. Lange Reconstruction of the RVOT with valved biological conduits: 25 years experience with allografts and xenografts Eur. J. Cardiothorac. Surg., June 1, 2000; 17(6): 624 - 630. [Abstract] [Full Text] [PDF]

				P. Biberthaler, N. Mendler, U. Ettner, and H. Meisner Endothelial prostacyclin (PGI-2) production of human and porcine valve allografts related to ischemic history Eur. J. Cardiothorac. Surg., November 1, 1999; 14(5): 503 - 507. [Abstract] [Full Text] [PDF]

				C. Hahn, S. K.C. Tam, G. J. Vlahakes, A. D. Hilgenberg, C. W. Akins, and M. J. Buckley Repeat aortic root replacement Ann. Thorac. Surg., July 1, 1998; 66(1): 88 - 91. [Abstract] [Full Text] [PDF]

				Y. C. Song, L. Y. Yao, J. M. Kneebone, and F. M. Lupinetti EFFECT OF CRYOPRESERVATION AND HISTOCOMPATIBILITY ON TYPE I PROCOLLAGEN GENE EXPRESSION IN AORTIC VALVE GRAFTS J. Thorac. Cardiovasc. Surg., September 1, 1997; 114(3): 421 - 427. [Abstract] [Full Text]

				R. C. Elkins, M. M. Lane, and C. McCue Pulmonary Autograft Reoperation: Incidence and Management Ann. Thorac. Surg., August 1, 1996; 62(2): 450 - 455. [Abstract] [Full Text]

				X. J. Feng, C. E. J. Van Hove, P. J. Walter, and A. G. Herman EFFECTS OF STORAGE TEMPERATURE AND FETAL CALF SERUM ON THE ENDOTHELIUM OF PORCINE AORTIC VALVES J. Thorac. Cardiovasc. Surg., January 1, 1996; 111(1): 218 - 230. [Abstract] [Full Text]

				M. G. Hazekamp, D. R. Koolbergen, J. Braun, H. Sugihara, C. J. Cornelisse, Y. A. Goffin, and H. A. Huysmans In situ hybridization: A new technique to determine the origin of fibroblasts in cryopreserved aortic homograft valve explants J. Thorac. Cardiovasc. Surg., July 1, 1995; 110(1): 248 - 257. [Abstract] [Full Text]