HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Personal Folders Download to citation manager Permission Requests Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Marini, C. P. Articles by Cunningham, J. N. Search for Related Content PubMed PubMed Citation Articles by Marini, C. P. Articles by Cunningham, J. N.

The Annals of Thoracic Surgery, Vol 47, 379-383, Copyright © 1989 by The Society of Thoracic Surgeons

ARTICLES

Effect of sodium nitroprusside on spinal cord perfusion and paraplegia during aortic cross-clamping

CP Marini, PE Grubbs, B Toporoff, TT Woloszyn, MS Coons, AJ Acinapura and JN Cunningham
Department of Surgery, Maimonides Medical Center, Brooklyn, NY 11219.

To evaluate the effects of sodium nitroprusside (SNP) on hemodynamics, cerebrospinal fluid dynamics, and neurological outcome after 30 minutes of thoracic aortic occlusion, we monitored proximal and distal blood pressure, cerebrospinal fluid pressure, spinal cord blood flow, and somatosensory evoked potentials. In group 1 (n = 6), no attempts were made to control proximal hypertension, whereas in group 2 (n = 6), proximal blood pressure was controlled with intravenous infusion of SNP. There was no significant difference in proximal or distal blood pressure or cerebrospinal fluid pressure between the two groups at baseline. During the crossclamp interval, the mean proximal aortic pressure rose from 108 +/- 21 to 146 +/- 14 mm Hg (p less than 0.001) in the control group, whereas the mean blood pressure in the SNP group was maintained at 99.8 +/- 12 mm Hg (p = not significant compared with baseline blood pressure). Mean distal aortic pressure decreased from systemic values to 23 +/- 7 mm Hg in control animals and to 11 +/- 5 mm Hg in the SNP group (p less than 0.005). In the latter group, cerebrospinal fluid pressure increased significantly from 10.6 +/- 1.9 to 20.1 +/- 5.5 mm Hg (p less than 0.005). In animals receiving SNP, spinal cord blood flow was decreased in the lower spinal cord segments and increased in the upper cord segments. When compared with controls, this difference did not reach significance.(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				R. A. Kahn, M. E. Stone, and D. M. Moskowitz Anesthetic Consideration for Descending Thoracic Aortic Aneurysm Repair Seminars in Cardiothoracic and Vascular Anesthesia, September 1, 2007; 11(3): 205 - 223. [Abstract] [PDF]

				C. L. Backer, R. D. Stewart, A. M. Kelle, and C. Mavroudis Use of partial cardiopulmonary bypass for coarctation repair through a left thoracotomy in children without collaterals. Ann. Thorac. Surg., September 1, 2006; 82(3): 964 - 972. [Abstract] [Full Text] [PDF]

				J. S. Coselli and P. L. Moreno Descending and Thoracoabdominal Aneurysm Card. Surg. Adult, January 1, 2003; 2(2003): 1169 - 1190. [Full Text]

				M. J. Williams Blunt and Penetrating Trauma to the Thoracic Aorta Seminars in Cardiothoracic and Vascular Anesthesia, June 1, 2002; 6(2): 77 - 81. [Abstract] [PDF]

				E. A. Hessel Bypass Techniques for Descending Thoracic Aortic Surgery Seminars in Cardiothoracic and Vascular Anesthesia, November 1, 2001; 5(4): 293 - 320. [Abstract] [PDF]

				I. S. Landsman and P. J. Davis Aortic Coarctation: Anesthetic Considerations Seminars in Cardiothoracic and Vascular Anesthesia, March 1, 2001; 5(1): 91 - 97. [Abstract] [PDF]

				A T. Ulus, U. Tutun, S. Surucu, N. Apaydin, P. Gokce, S F. Katircioglu, A T. Ulus, U. Tutun, S. Surucu, N. Apaydin, et al. Functional Outcome in Model of Spinal Cord Ischemia: Use of Enoximone Asian Cardiovasc Thorac Ann, September 1, 2000; 8(3): 216 - 220. [Abstract] [Full Text] [PDF]

				C. Wong Paraplegia after coronary artery bypass operations: Relationship to severe hypertension and vascular disease J. Thorac. Cardiovasc. Surg., June 1, 2000; 119(6): 1295 - 1296. [Full Text]

				J. D. Galla, M. A. Ergin, S. L. Lansman, J. N. McCullough, K. H. Nguyen, D. Spielvogel, J. J. Klein, and R. B. Griepp Use of somatosensory evoked potentials for thoracic and thoracoabdominal aortic resections Ann. Thorac. Surg., June 1, 1999; 67(6): 1947 - 1952. [Abstract] [Full Text] [PDF]

				Y. Taira, M. Marsala, and W. I. Rosenblum Effect of Proximal Arterial Perfusion Pressure on Function, Spinal Cord Blood Flow, and Histopathologic Changes After Increasing Intervals of Aortic Occlusion in the Rat Stroke, October 1, 1996; 27(10): 1850 - 1858. [Abstract] [Full Text]

				J. I. Simpson, T. R. Eide, G. A. Schiff, S. B. Newman, J. F. Clagnaz, I. Hossain, S. B. Schulman, and J. E. Gropper Effect of Nitroglycerin on Spinal Cord Ischemia After Thoracic Aortic Cross-Clamping Ann. Thorac. Surg., January 1, 1996; 61(1): 113 - 117. [Abstract] [Full Text]

				A. Olah, A. C. Cernaianu, T. Gaprindashvili, J. H. Cilley JR, M. M. Neuwirth, N. Ansari, and A. J. DelRossi Improvement of Spinal Cord Electrical Activity with Lazaroid (U74006F) During Operations on the Thoracic Aorta: Evaluation of a Novel Lipid Peroxidation Inhibitor Vascular and Endovascular Surgery, July 1, 1994; 28(6): 377 - 381. [Abstract] [PDF]