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The Annals of Thoracic Surgery, Vol 47, 151-157, Copyright © 1989 by The Society of Thoracic Surgeons

ARTICLES

Total artificial heart: survival and complications

C Muneretto, E Solis, A Pavie, P Leger, I Gandjbakhch, J Szefner, V Bors, C Piazza, A Cabrol and C Cabrol
Department of Cardio-Thoracic Surgery, La Pitie Hospital, Paris, France.

A total artificial heart was implanted in 28 patients as a bridge to transplantation. Mean time of mechanical support was 14.8 +/- 10 days. The 70-mL Jarvik-7 was used in 12 patients and the 100-mL Jarvik-7 in the remaining 16. No clinical thromboembolic complications occurred during implantation. There was no postoperative bleeding requiring operation. Both survival and the rate of complications were similar in the two Jarvik-7 groups. Eleven patients underwent successful transplantation, and 1 patient is still on mechanical support. Sepsis and multiple-organ failure were the most important causes of death. All patients receiving the total artificial heart for severe acute rejection after transplantation died of infection. Early implantation of the total artificial heart is advised in younger patients and in older patients with acute cardiac failure. The use of this device should be contraindicated in immunosuppressed patients because of the high risk of infection.

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